| Literature DB >> 23411704 |
Yasuko Koma1, Keiko Goto, Chihiro Yoshida, Kengo Kimura, Yusuke Matsumoto, Midori Koyama, Nariyasu Nakashima, Daiki Masuya, Hirofumi Matsuoka, Harukazu Yoshimatsu, Yujiro Suzuki.
Abstract
An 84-year-old woman being treated for miliary tuberculosis (TB) with rifampicin (RFP), isoniazid (INH), ethambutol (EB) and corticosteroids suffered from a persistent fever for five months. While tapering the dose of prednisolone, chest computed tomography (CT) revealed diffuse ground glass opacities (GGO) and bronchoalveolar lavage fluid (BALF) showed an increase in lymphocytes. After the anti-TB drugs were discontinued and the dose of the corticosteroids was increased, the CT findings and fever improved considerably. However, readministration of RFP provoked an inflammatory reaction, leading to a diagnosis of RFP-induced pneumonitis. This condition is very rare. This is the first report of RFP-induced pneumonitis occurring during adjunct steroid therapy.Entities:
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Year: 2013 PMID： 23411704 DOI： 10.2169/internalmedicine.52.8997
Source DB: PubMed Journal: Intern Med ISSN： 0918-2918 Impact factor: 1.271