Literature DB >> 23410073

Cascade synthesis of fenpiprane and related pharmaceuticals via rhodium-catalyzed hydroaminomethylation.

Shengkun Li1, Kexuan Huang, Jiwen Zhang, Wenjun Wu, Xumu Zhang.   

Abstract

A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.

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Year:  2013        PMID: 23410073     DOI: 10.1021/ol303483t

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Continuous Flow Preparation of Benzylic Sodium Organometallics.

Authors:  Johannes H Harenberg; Rajasekar Reddy Annapureddy; Konstantin Karaghiosoff; Paul Knochel
Journal:  Angew Chem Int Ed Engl       Date:  2022-05-11       Impact factor: 16.823

  1 in total

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