BACKGROUND AND OBJECTIVES: Although the association between single nucleotide polymorphisms (SNPs) of Serine/Threonine Kinase 39 (STK39) and hypertension has been reported, the prior studies have been inconsistent. The aim of this study is to evaluate the association between rs3754777 and rs6749447, the two SNPs of STK39, and hypertension and other cardiovascular risk factors in Koreans, residing in the Republic of Korea. SUBJECTS AND METHODS: We included 238 hypertensive patients and 260 controls. The associations between genotype and haplotype combination and hypertension were examined. In addition, possible SNP-related differences in the adjusted blood pressure and other cardiovascular risk factors were analyzed. RESULTS: There was no significant association between the two SNPs and hypertension. However, the carriers of AA genotype of rs3754777 showed lower blood glucose and cholesterol levels, particularly in females. Genotype of rs6749447 was associated with the waist circumference, triglyceride, and high density lipoprotein-cholesterol levels, only in gender-stratified analysis. The effects of haplotype combinations on risk factors were compatible with genotype effects of each SNP. CONCLUSION: Associations between the two SNPs of STK39, rs3754777 and rs6749447, and hypertension were not significant. However, the two SNPs showed genotype-related differences in blood glucose, lipids, and waist circumference, especially in women. Further studies are needed to clarify the effect of STK39 variants in these cardiovascular risk factors.
BACKGROUND AND OBJECTIVES: Although the association between single nucleotide polymorphisms (SNPs) of Serine/Threonine Kinase 39 (STK39) and hypertension has been reported, the prior studies have been inconsistent. The aim of this study is to evaluate the association between rs3754777 and rs6749447, the two SNPs of STK39, and hypertension and other cardiovascular risk factors in Koreans, residing in the Republic of Korea. SUBJECTS AND METHODS: We included 238 hypertensivepatients and 260 controls. The associations between genotype and haplotype combination and hypertension were examined. In addition, possible SNP-related differences in the adjusted blood pressure and other cardiovascular risk factors were analyzed. RESULTS: There was no significant association between the two SNPs and hypertension. However, the carriers of AA genotype of rs3754777 showed lower blood glucose and cholesterol levels, particularly in females. Genotype of rs6749447 was associated with the waist circumference, triglyceride, and high density lipoprotein-cholesterol levels, only in gender-stratified analysis. The effects of haplotype combinations on risk factors were compatible with genotype effects of each SNP. CONCLUSION: Associations between the two SNPs of STK39, rs3754777 and rs6749447, and hypertension were not significant. However, the two SNPs showed genotype-related differences in blood glucose, lipids, and waist circumference, especially in women. Further studies are needed to clarify the effect of STK39 variants in these cardiovascular risk factors.
Authors: Daniel Levy; Georg B Ehret; Kenneth Rice; Germaine C Verwoert; Lenore J Launer; Abbas Dehghan; Nicole L Glazer; Alanna C Morrison; Andrew D Johnson; Thor Aspelund; Yurii Aulchenko; Thomas Lumley; Anna Köttgen; Ramachandran S Vasan; Fernando Rivadeneira; Gudny Eiriksdottir; Xiuqing Guo; Dan E Arking; Gary F Mitchell; Francesco U S Mattace-Raso; Albert V Smith; Kent Taylor; Robert B Scharpf; Shih-Jen Hwang; Eric J G Sijbrands; Joshua Bis; Tamara B Harris; Santhi K Ganesh; Christopher J O'Donnell; Albert Hofman; Jerome I Rotter; Josef Coresh; Emelia J Benjamin; André G Uitterlinden; Gerardo Heiss; Caroline S Fox; Jacqueline C M Witteman; Eric Boerwinkle; Thomas J Wang; Vilmundur Gudnason; Martin G Larson; Aravinda Chakravarti; Bruce M Psaty; Cornelia M van Duijn Journal: Nat Genet Date: 2009-05-10 Impact factor: 38.330
Authors: Ying Wang; Jeffrey R O'Connell; Patrick F McArdle; James B Wade; Sarah E Dorff; Sanjiv J Shah; Xiaolian Shi; Lin Pan; Evadnie Rampersaud; Haiqing Shen; James D Kim; Arohan R Subramanya; Nanette I Steinle; Afshin Parsa; Carole C Ober; Paul A Welling; Aravinda Chakravarti; Alan B Weder; Richard S Cooper; Braxton D Mitchell; Alan R Shuldiner; Yen-Pei C Chang Journal: Proc Natl Acad Sci U S A Date: 2008-12-29 Impact factor: 11.205
Authors: Michael S Cunnington; Chris Kay; Peter J Avery; Bongani M Mayosi; Mauro Santibanez Koref; Bernard Keavney Journal: BMC Med Genet Date: 2009-12-14 Impact factor: 2.103
Authors: Christopher Newton-Cheh; Toby Johnson; Vesela Gateva; Martin D Tobin; Murielle Bochud; Lachlan Coin; Samer S Najjar; Jing Hua Zhao; Simon C Heath; Susana Eyheramendy; Konstantinos Papadakis; Benjamin F Voight; Laura J Scott; Feng Zhang; Martin Farrall; Toshiko Tanaka; Chris Wallace; John C Chambers; Kay-Tee Khaw; Peter Nilsson; Pim van der Harst; Silvia Polidoro; Diederick E Grobbee; N Charlotte Onland-Moret; Michiel L Bots; Louise V Wain; Katherine S Elliott; Alexander Teumer; Jian'an Luan; Gavin Lucas; Johanna Kuusisto; Paul R Burton; David Hadley; Wendy L McArdle; Morris Brown; Anna Dominiczak; Stephen J Newhouse; Nilesh J Samani; John Webster; Eleftheria Zeggini; Jacques S Beckmann; Sven Bergmann; Noha Lim; Kijoung Song; Peter Vollenweider; Gerard Waeber; Dawn M Waterworth; Xin Yuan; Leif Groop; Marju Orho-Melander; Alessandra Allione; Alessandra Di Gregorio; Simonetta Guarrera; Salvatore Panico; Fulvio Ricceri; Valeria Romanazzi; Carlotta Sacerdote; Paolo Vineis; Inês Barroso; Manjinder S Sandhu; Robert N Luben; Gabriel J Crawford; Pekka Jousilahti; Markus Perola; Michael Boehnke; Lori L Bonnycastle; Francis S Collins; Anne U Jackson; Karen L Mohlke; Heather M Stringham; Timo T Valle; Cristen J Willer; Richard N Bergman; Mario A Morken; Angela Döring; Christian Gieger; Thomas Illig; Thomas Meitinger; Elin Org; Arne Pfeufer; H Erich Wichmann; Sekar Kathiresan; Jaume Marrugat; Christopher J O'Donnell; Stephen M Schwartz; David S Siscovick; Isaac Subirana; Nelson B Freimer; Anna-Liisa Hartikainen; Mark I McCarthy; Paul F O'Reilly; Leena Peltonen; Anneli Pouta; Paul E de Jong; Harold Snieder; Wiek H van Gilst; Robert Clarke; Anuj Goel; Anders Hamsten; John F Peden; Udo Seedorf; Ann-Christine Syvänen; Giovanni Tognoni; Edward G Lakatta; Serena Sanna; Paul Scheet; David Schlessinger; Angelo Scuteri; Marcus Dörr; Florian Ernst; Stephan B Felix; Georg Homuth; Roberto Lorbeer; Thorsten Reffelmann; Rainer Rettig; Uwe Völker; Pilar Galan; Ivo G Gut; Serge Hercberg; G Mark Lathrop; Diana Zelenika; Panos Deloukas; Nicole Soranzo; Frances M Williams; Guangju Zhai; Veikko Salomaa; Markku Laakso; Roberto Elosua; Nita G Forouhi; Henry Völzke; Cuno S Uiterwaal; Yvonne T van der Schouw; Mattijs E Numans; Giuseppe Matullo; Gerjan Navis; Göran Berglund; Sheila A Bingham; Jaspal S Kooner; John M Connell; Stefania Bandinelli; Luigi Ferrucci; Hugh Watkins; Tim D Spector; Jaakko Tuomilehto; David Altshuler; David P Strachan; Maris Laan; Pierre Meneton; Nicholas J Wareham; Manuela Uda; Marjo-Riitta Jarvelin; Vincent Mooser; Olle Melander; Ruth J F Loos; Paul Elliott; Gonçalo R Abecasis; Mark Caulfield; Patricia B Munroe Journal: Nat Genet Date: 2009-05-10 Impact factor: 38.330
Authors: Javad Jamshidi; Ali Asnaashari; Reza Alipoor; Sina Mohammadi; Sara Roostaei; Mohammad Mahdi Samadian; Saiedeh Honarmand Aliabadi; Ehsan Bahramali Journal: Med J Islam Repub Iran Date: 2018-02-20