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Literature DB >> 23408628

Antibody-DEPENDENT, FcγRI-mediated neutralization of HIV-1 in TZM-bl cells occurs independently of phagocytosis.

Lautaro G Perez¹, Susan Zolla-Pazner, David C Montefiori.

Abstract

We previously showed that expression of human FcγRI on TZM-bl cells potentiates neutralization by gp41 membrane-proximal external region (MPER)-specific antibodies. Here we show that lysosomotropic reagents known to block phagocytosis do not diminish this effect. We also show that FcγRI occasionally potentiates neutralization by antibodies against the V3 loop of gp120 and cluster I of gp41. We conclude that FcγRI provides a kinetic advantage for neutralizing antibodies against partially cryptic epitopes independent of phagocytosis.

Entities: CellLine Gene Species

Mesh：

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Year: 2013 PMID： 23408628 PMCID： PMC3624318 DOI： 10.1128/JVI.00278-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

42 in total

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