Literature DB >> 23408622

A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity but not the transmission of Egyptian highly pathogenic H5N1 influenza virus in chickens.

Sun-Woo Yoon1, Ghazi Kayali, Mohamed A Ali, Robert G Webster, Richard J Webby, Mariette F Ducatez.   

Abstract

Highly pathogenic avian influenza (HPAI) virus H5N1 has been enzootic in Egypt since 2008. Virus-associated mortality (but not the number of cases) in humans and poultry seems to have decreased over time, but the reason for this remains unknown. We investigated the role of a single amino acid substitution in the hemagglutinin cleavage site on virus pathogenicity and transmission in chickens. The R325G substitution significantly reduced pathogenicity without altering the transmission efficiency of HPAI H5N1 virus.

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Year:  2013        PMID： 23408622      PMCID： PMC3624353          DOI： 10.1128/JVI.03551-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

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Authors:  Amorsolo L Suguitan; Yumiko Matsuoka; Yuk-Fai Lau; Celia P Santos; Leatrice Vogel; Lily I Cheng; Marlene Orandle; Kanta Subbarao
Journal:  J Virol       Date:  2011-12-28       Impact factor: 5.103

2.  Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses.

Authors:  M L Perdue; M García; D Senne; M Fraire
Journal:  Virus Res       Date:  1997-06       Impact factor: 3.303

Review 3.  Role of hemagglutinin cleavage for the pathogenicity of influenza virus.

Authors:  D A Steinhauer
Journal:  Virology       Date:  1999-05-25       Impact factor: 3.616

4.  Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong.

Authors:  X Xu; N J Cox; Y Guo
Journal:  Virology       Date:  1999-08-15       Impact factor: 3.616

Review 5.  Pandemic influenza as a current threat.

Authors:  Hui-Ling Yen; Robert G Webster
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6.  Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus.

Authors:  T Horimoto; Y Kawaoka
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

7.  Proteolytic cleavage of influenza virus hemagglutinins: primary structure of the connecting peptide between HA1 and HA2 determines proteolytic cleavability and pathogenicity of Avian influenza viruses.

Authors:  F X Bosch; W Garten; H D Klenk; R Rott
Journal:  Virology       Date:  1981-09       Impact factor: 3.616

8.  Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.

Authors:  A Stieneke-Gröber; M Vey; H Angliker; E Shaw; G Thomas; C Roberts; H D Klenk; W Garten
Journal:  EMBO J       Date:  1992-07       Impact factor: 11.598

9.  The epidemiological and molecular aspects of influenza H5N1 viruses at the human-animal interface in Egypt.

Authors:  Ghazi Kayali; Richard J Webby; Mariette F Ducatez; Rabeh A El Shesheny; Ahmed M Kandeil; Elena A Govorkova; Ahmed Mostafa; Mohamed A Ali
Journal:  PLoS One       Date:  2011-03-21       Impact factor: 3.240

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Journal:  J Mol Genet Med       Date:  2009-12-09
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  10 in total

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2.  Molecular characterization of avian influenza H5N1 virus in Egypt and the emergence of a novel endemic subclade.

Authors:  Rabeh El-Shesheny; Ahmed Kandeil; Ola Bagato; Asmaa M Maatouq; Yassmin Moatasim; Adam Rubrum; Min-Suk Song; Richard J Webby; Mohamed Ahmed Ali; Ghazi Kayali
Journal:  J Gen Virol       Date:  2014-04-10       Impact factor: 3.891

3.  Refining the approach to vaccines against influenza A viruses with pandemic potential.

Authors:  Rita Czako; Kanta Subbarao
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4.  Combining phylogeography and spatial epidemiology to uncover predictors of H5N1 influenza A virus diffusion.

Authors:  Daniel Magee; Rachel Beard; Marc A Suchard; Philippe Lemey; Matthew Scotch
Journal:  Arch Virol       Date:  2014-10-30       Impact factor: 2.574

5.  In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses.

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Journal:  Sci Rep       Date:  2015-06-19       Impact factor: 4.379

6.  Generalized linear models for identifying predictors of the evolutionary diffusion of viruses.

Authors:  Rachel Beard; Daniel Magee; Marc A Suchard; Philippe Lemey; Matthew Scotch
Journal:  AMIA Jt Summits Transl Sci Proc       Date:  2014-04-07

7.  Efficient generation of recombinant influenza A viruses employing a new approach to overcome the genetic instability of HA segments.

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Journal:  PLoS One       Date:  2015-01-23       Impact factor: 3.240

Review 8.  Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif.

Authors:  Jasmina M Luczo; John Stambas; Peter A Durr; Wojtek P Michalski; John Bingham
Journal:  Rev Med Virol       Date:  2015-10-15       Impact factor: 6.989

9.  Unlocking pandemic potential: prevalence and spatial patterns of key substitutions in avian influenza H5N1 in Egyptian isolates.

Authors:  Sean G Young; Andrew Kitchen; Ghazi Kayali; Margaret Carrel
Journal:  BMC Infect Dis       Date:  2018-07-06       Impact factor: 3.090

10.  Phylodynamics of avian influenza clade 2.2.1 H5N1 viruses in Egypt.

Authors:  Abdelsatar Arafa; Ihab El-Masry; Shereen Kholosy; Mohammed K Hassan; Gwenaelle Dauphin; Juan Lubroth; Yilma J Makonnen
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  10 in total

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