Literature DB >> 2340854

Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat.

F Chaouloff1, V Baudrie, D Laude.   

Abstract

The aim of this study was to investigate the effects of the 5-HT1A receptor agonists buspirone and ipsapirone (1-10 mg/kg) on plasma adrenaline (A) levels and on glycemia in the conscious rat. The results indicate that buspirone was able, within 5 min, to increase plasma A and glucose levels in a dose-dependent manner. Ipsapirone administration triggered similar patterns, except that the highest dose used (10 mg/kg) promoted a time-dependent increase in plasma A and glucose levels that was maximal at the end of analysis.

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Year:  1990        PMID： 2340854     DOI： 10.1016/0014-2999(90)90558-n

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Effect of buspirone: An anxiolytic drug on blood glucose in humans.

Authors:  S K Ojha; M Nandave; C Sharma
Journal:  Indian J Clin Biochem       Date:  2006-09

2.  Effects of the 5-HT1 receptor agonists DP-5-CT, CGS 12066B, and RU 24969 on plasma adrenaline and glucose levels in the rat.

Authors:  D Laude; V Baudrie; G R Martin; F Chaouloff
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-10       Impact factor: 3.000

3.  Decreased 5-HT1A receptor gene expression and 5-HT1A receptor protein in the cerebral cortex and brain stem during pancreatic regeneration in rats.

Authors:  Valiya veettil Mohanan; S Balarama Kaimal; Cheramadathikudyil S Paulose
Journal:  Neurochem Res       Date:  2005-01       Impact factor: 3.996

4.  Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine.

Authors:  I Berlin; S Chalon; C Payan; G Schöllnhammer; F Cesselin; O Varoquaux; A J Puech
Journal:  Br J Clin Pharmacol       Date:  1995-03       Impact factor: 4.335

5.  Role of the adrenal medulla in the metabolic and pressor actions of 8-OH-DPAT.

Authors:  R Bouhelal; A K Mir
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

6.  Cardiovascular effects of intrathecal administration of substance P in the rat: interactions with serotonergic mechanisms.

Authors:  K Gradin; B Persson
Journal:  J Neural Transm Gen Sect       Date:  1992

7.  Central administration of 5-HT activates 5-HT1A receptors to cause sympathoexcitation and 5-HT2/5-HT1C receptors to release vasopressin in anaesthetized rats.

Authors:  I K Anderson; G R Martin; A G Ramage
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

8.  Evidence that 5-HT1A receptors are involved in the adrenaline-releasing effects of 8-OH-DPAT in the conscious rat.

Authors:  F Chaouloff; V Baudrie; D Laude
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000
  8 in total

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