Frustrated Lewis Pairs: from dihydrogen activation to asymmetric catalysis.

The non-self-quenched property of Frustrated Lewis Pairs (FLPs) contradicts the classical Lewis acid-base theory, but this peculiarity offers unprecedented possibilities for the activation of small molecules. Among all of their fascinating applications, FLP mediated hydrogen activation and the associated catalytic hydrogenations are currently considered as the most intriguing illustration of their reactivity. The FLPs enabled the catalytic reduction of a wide range of substrates with molecular hydrogen and tuning of the structural properties of the FLP partners allowed broadening of the substrate scope. Based on detailed mechanistic knowledge, FLP based asymmetric hydrogenation of various substrates could be achieved with high enantioselectivities. More importantly, FLP based enantioselective catalysis is not limited to the field of asymmetric hydrogenation, and other exciting catalytic applications have already appeared.