BACKGROUND: This study evaluates the risk of benign brain tumors (BBTs) and malignant brain tumors (MBTs) associated with dental diagnostic X-ray, using a large population-based case-control study. MATERIALS AND METHODS: We identified 4123 BBT cases and 16 492 controls without BBT (study 1) and 197 MBT cases and 788 controls without MBT (study 2) from Taiwan National Health Insurance claim data. The risks of both types of tumor were estimated in association with the frequency of received dental diagnostic X-ray. RESULTS: The mean ages were ~44.2 years in study 1 and 40.6 years in study 2. Multivariable unconditional logistic regression analysis showed that the risk of BBT increases as the frequency of received dental diagnostic X-ray increases. The BBT odds ratio increased from 1.33 [95% confidence interval (CI) 1.22-1.44] for those with annual mean X-ray examination of less than one to 1.65 (95% CI 1.37-1.98) for those with three or more X-ray examinations, after controlling for comorbidities. No significant association was found between MBTs and dental diagnostic X-ray exposure. CONCLUSIONS: Exposure to dental diagnostic X-rays in oral and maxillofacial care increases the risk of BBTs, but not MBTs.
BACKGROUND: This study evaluates the risk of benign brain tumors (BBTs) and malignant brain tumors (MBTs) associated with dental diagnostic X-ray, using a large population-based case-control study. MATERIALS AND METHODS: We identified 4123 BBT cases and 16 492 controls without BBT (study 1) and 197 MBT cases and 788 controls without MBT (study 2) from Taiwan National Health Insurance claim data. The risks of both types of tumor were estimated in association with the frequency of received dental diagnostic X-ray. RESULTS: The mean ages were ~44.2 years in study 1 and 40.6 years in study 2. Multivariable unconditional logistic regression analysis showed that the risk of BBT increases as the frequency of received dental diagnostic X-ray increases. The BBT odds ratio increased from 1.33 [95% confidence interval (CI) 1.22-1.44] for those with annual mean X-ray examination of less than one to 1.65 (95% CI 1.37-1.98) for those with three or more X-ray examinations, after controlling for comorbidities. No significant association was found between MBTs and dental diagnostic X-ray exposure. CONCLUSIONS: Exposure to dental diagnostic X-rays in oral and maxillofacial care increases the risk of BBTs, but not MBTs.
Entities:
Keywords:
Taiwan Health Insurance; brain tumors; dental X-ray exposure
Authors: Reinhilde Jacobs; Ruben Pauwels; William C Scarfe; Carl De Cock; Karl Dula; Guy Willems; An Verdonck; Constantinus Politis Journal: Clin Oral Investig Date: 2017-11-29 Impact factor: 3.573
Authors: Anssi Auvinen; Elisabeth Cardis; Maria Blettner; Monika Moissonnier; Siegal Sadetzki; Graham Giles; Christoffer Johansen; Anthony Swerdlow; Angus Cook; Sarah Fleming; Gabriele Berg-Beckhoff; Ivano Iavarone; Marie-Elise Parent; Alistair Woodward; Tore Tynes; Mary McBride; Dan Krewski; Maria Feychting; Toru Takebayashi; Bruce Armstrong; Martine Hours; Jack Siemiatycki; Susanna Lagorio; Signe Benzon Larsen; Minouk Schoemaker; Lars Klaeboe; Stefan Lönn; Joachim Schüz Journal: Int J Epidemiol Date: 2022-05-09 Impact factor: 9.685