UNLABELLED: We initiated a pilot study to investigate the effects of 8 wks of aerobic exercise training (ET) on insulin sensitivity and inflammatory markers in obese and insulin-resistant minority adolescents. Eleven morbidly obese (BMI 41.4 ± 1.8 kg/m2) minority adolescents were entered into a supervised ET intervention (~180 min/wk at 40-55%VO2PeakR [(VO2Peak-VO2Rest)/VO2Rest]). The effects of training on insulin sensitivity (SI), inflammation and other metabolic syndrome features were examined. RESULTS: Insulin action improved in response to training, as indicated by a ~37% increase in SI (p = .018). Plasma levels of several proinflammatory cytokines were reduced in response to ET, as indicated by significant decrements in sTNF-R, CCL2, MPO, IL-6, resistin, and leptin, with no significant changes in hsCRP. ET induced reductions in BMI and percent total body fat. CONCLUSIONS: The present study supports the efficacy of ET interventions on metabolic syndrome features in morbidly obese minority youth.
UNLABELLED: We initiated a pilot study to investigate the effects of 8 wks of aerobic exercise training (ET) on insulin sensitivity and inflammatory markers in obese and insulin-resistant minority adolescents. Eleven morbidly obese (BMI 41.4 ± 1.8 kg/m2) minority adolescents were entered into a supervised ET intervention (~180 min/wk at 40-55%VO2PeakR [(VO2Peak-VO2Rest)/VO2Rest]). The effects of training on insulin sensitivity (SI), inflammation and other metabolic syndrome features were examined. RESULTS: Insulin action improved in response to training, as indicated by a ~37% increase in SI (p = .018). Plasma levels of several proinflammatory cytokines were reduced in response to ET, as indicated by significant decrements in sTNF-R, CCL2, MPO, IL-6, resistin, and leptin, with no significant changes in hsCRP. ET induced reductions in BMI and percent total body fat. CONCLUSIONS: The present study supports the efficacy of ET interventions on metabolic syndrome features in morbidly obese minority youth.
Authors: Itahisa Marcelino-Rodríguez; Delia Almeida Gonzalez; José Juan Alemán-Sánchez; Buenaventura Brito Díaz; María Del Cristo Rodríguez Pérez; Fadoua Gannar; Santiago Domínguez Coello; Francisco J Cuevas Fernández; Antonio Cabrera de León Journal: PLoS One Date: 2017-08-03 Impact factor: 3.240
Authors: Angeles Bonal Rosell Rayes; Claudio Andre B de Lira; Ricardo B Viana; Ana A Benedito-Silva; Rodrigo L Vancini; Naryana Mascarin; Marilia S Andrade Journal: PeerJ Date: 2019-02-28 Impact factor: 2.984