| Literature DB >> 23406520 |
Xudong Wei1, Chutian Shu, Nizar Haddad, Xingzhong Zeng, Nitinchandra D Patel, Zhulin Tan, Jianxiu Liu, Heewon Lee, Sherry Shen, Scot Campbell, Richard J Varsolona, Carl A Busacca, Azad Hossain, Nathan K Yee, Chris H Senanayake.
Abstract
A highly convergent large scale synthesis of a 15-membered macrocyclic hepatitis C virus (HCV) protease inhibitor BI 201302 was achieved, in which the key features are the practical macrocyclization by Ru-catalyzed ring-closing metathesis (0.1 mol % Grela catalyst, 0.1-0.2 M concentration) and the efficient sulfone-mediated SNAr reaction.Entities:
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Year: 2013 PMID： 23406520 DOI： 10.1021/ol303498m
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005