BACKGROUND: Testosterone is measured for the investigation of female hyperandrogenism and male hypogonadism. Liquid chromatography-tandem mass spectrometry (tandem MS) is becoming the method of choice but comprehensive reference ranges are lacking. METHODS: Testosterone was measured by tandem MS on 90 healthy women, 67 young healthy men and pregnant women (59 first trimester and 60 second trimester). RESULTS: The male, male calculated free, first trimester and second trimester testosterone reference ranges (derived using the antilog of mean ± 1.96 SD of log transformed data) were 10.6-31.9, 0.23-0.63, 0.6-4.9 and 0.9-4.9 nmol/L, respectively. The female testosterone upper reference range limit, derived non-parametrically from the 97.5th centile, was <1.7 nmol/L. CONCLUSIONS: We have derived tandem MS testosterone reference ranges to support clinical services.
BACKGROUND:Testosterone is measured for the investigation of female hyperandrogenism and male hypogonadism. Liquid chromatography-tandem mass spectrometry (tandem MS) is becoming the method of choice but comprehensive reference ranges are lacking. METHODS:Testosterone was measured by tandem MS on 90 healthy women, 67 young healthy men and pregnant women (59 first trimester and 60 second trimester). RESULTS: The male, male calculated free, first trimester and second trimester testosterone reference ranges (derived using the antilog of mean ± 1.96 SD of log transformed data) were 10.6-31.9, 0.23-0.63, 0.6-4.9 and 0.9-4.9 nmol/L, respectively. The female testosterone upper reference range limit, derived non-parametrically from the 97.5th centile, was <1.7 nmol/L. CONCLUSIONS: We have derived tandem MS testosterone reference ranges to support clinical services.
Authors: R Bove; A Musallam; B C Healy; K Raghavan; B I Glanz; R Bakshi; H Weiner; P L De Jager; K K Miller; T Chitnis Journal: Mult Scler Date: 2014-04-07 Impact factor: 6.312
Authors: Maria João Gouveia; Paul J Brindley; Lúcio Lara Santos; José Manuel Correia da Costa; Paula Gomes; Nuno Vale Journal: Metabolism Date: 2013-05-07 Impact factor: 8.694
Authors: Myrna Buenaluz-Sedurante; Mark Isaiah K Co; Daryl Jade T Dagang; Racquel G Bruno; Annie Jane N Sarmiento; Michael L Tee Journal: Int J Endocrinol Date: 2020-11-28 Impact factor: 3.257