Literature DB >> 23403863

Differential loss of invariant natural killer T cells and FoxP3⁺ regulatory T cells in HIV-1 subtype A and subtype D infections.

Britta Flach1, Prossy Naluyima, Kim Blom, Veronica D Gonzalez, Leigh Anne Eller, Oliver Laeyendecker, Thomas C Quinn, David Serwadda, Nelson K Sewankambo, Maria J Wawer, Ronald H Gray, Nelson L Michael, Fred Wabwire-Mangen, Merlin L Robb, Michael A Eller, Johan K Sandberg.   

Abstract

HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3⁺ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.

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Year:  2013        PMID： 23403863      PMCID： PMC3683089          DOI： 10.1097/QAI.0b013e31828b2073

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  30 in total

1.  Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex.

Authors:  Sungyoo Cho; Kenneth S Knox; Lisa M Kohli; Johnny J He; Mark A Exley; S Brian Wilson; Randy R Brutkiewicz
Journal:  Virology       Date:  2005-07-05       Impact factor: 3.616

2.  Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection.

Authors:  Hans J J van der Vliet; B Mary E von Blomberg; Mette D Hazenberg; Nobusuke Nishi; Sigrid A Otto; Birgit H van Benthem; Maria Prins; Frans A Claessen; Alfons J M van den Eertwegh; Giuseppe Giaccone; Frank Miedema; Rik J Scheper; Herbert M Pinedo
Journal:  J Immunol       Date:  2002-02-01       Impact factor: 5.422

3.  Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment.

Authors:  Brinda Emu; Elizabeth Sinclair; David Favre; Walter J Moretto; Priscilla Hsue; Rebecca Hoh; Jeffrey N Martin; Douglas F Nixon; Joseph M McCune; Steven G Deeks
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

4.  Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda.

Authors:  Pontiano Kaleebu; Neil French; Cedric Mahe; David Yirrell; Christine Watera; Fred Lyagoba; Jessica Nakiyingi; Alleluiah Rutebemberwa; Dilys Morgan; Jonathan Weber; Charles Gilks; Jimmy Whitworth
Journal:  J Infect Dis       Date:  2002-04-16       Impact factor: 5.226

5.  Preferential depletion of gut CD4-expressing iNKT cells contributes to systemic immune activation in HIV-1 infection.

Authors:  F J Ibarrondo; S B Wilson; L E Hultin; R Shih; M A Hausner; P M Hultin; P A Anton; B D Jamieson; O O Yang
Journal:  Mucosal Immunol       Date:  2012-11-14       Impact factor: 7.313

6.  Human immunodeficiency virus type 1 subtypes differ in disease progression.

Authors:  P J Kanki; D J Hamel; J L Sankalé; C c Hsieh; I Thior; F Barin; S A Woodcock; A Guèye-Ndiaye; E Zhang; M Montano; T Siby; R Marlink; I NDoye; M E Essex; S MBoup
Journal:  J Infect Dis       Date:  1999-01       Impact factor: 5.226

7.  Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection.

Authors:  Mark J Boaz; Anele Waters; Shahed Murad; Philippa J Easterbrook; Annapurna Vyakarnam
Journal:  J Immunol       Date:  2002-12-01       Impact factor: 5.422

8.  Selective loss of innate CD4(+) V alpha 24 natural killer T cells in human immunodeficiency virus infection.

Authors:  Johan K Sandberg; Noam M Fast; Emil H Palacios; Glenn Fennelly; Joanna Dobroszycki; Paul Palumbo; Andrew Wiznia; Robert M Grant; Nina Bhardwaj; Michael G Rosenberg; Douglas F Nixon
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103

9.  Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy.

Authors:  Alexandre Harari; Stéphanie Petitpierre; Florence Vallelian; Giuseppe Pantaleo
Journal:  Blood       Date:  2003-09-04       Impact factor: 22.113

10.  CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status.

Authors:  Audrey L Kinter; Margaret Hennessey; Alicia Bell; Sarah Kern; Yin Lin; Marybeth Daucher; Maria Planta; Mary McGlaughlin; Robert Jackson; Steven F Ziegler; Anthony S Fauci
Journal:  J Exp Med       Date:  2004-07-26       Impact factor: 14.307
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  3 in total

1.  Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.

Authors:  Dominic Paquin-Proulx; Anna Gibbs; Susanna M Bächle; Antonio Checa; Andrea Introini; Edwin Leeansyah; Craig E Wheelock; Douglas F Nixon; Kristina Broliden; Annelie Tjernlund; Markus Moll; Johan K Sandberg
Journal:  J Immunol       Date:  2016-08-01       Impact factor: 5.422

2.  HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.

Authors:  Michael A Eller; Marc S Opollo; Michelle Liu; Andrew D Redd; Leigh Anne Eller; Cissy Kityo; Joshua Kayiwa; Oliver Laeyendecker; Maria J Wawer; Mark Milazzo; Noah Kiwanuka; Ronald H Gray; David Serwadda; Nelson K Sewankambo; Thomas C Quinn; Nelson L Michael; Fred Wabwire-Mangen; Johan K Sandberg; Merlin L Robb
Journal:  J Infect Dis       Date:  2014-11-17       Impact factor: 5.226

3.  Impaired natural killer cell responses are associated with loss of the highly activated NKG2A(+)CD57(+)CD56(dim) subset in HIV-1 subtype D infection in Uganda.

Authors:  Prossy Naluyima; Michael A Eller; Oliver Laeyendecker; Thomas C Quinn; David Serwadda; Nelson K Sewankambo; Ronald H Gray; Nelson L Michael; Fred Wabwire-Mangen; Merlin L Robb; Johan K Sandberg
Journal:  AIDS       Date:  2014-06-01       Impact factor: 4.177
  3 in total

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