PURPOSE OF REVIEW: Liver dysfunction frequently complicates the clinical picture of critical illness and leads to increased morbidity and mortality. The purpose of this review is to characterize the most frequent patterns of liver dysfunction at the intensive care unit, cholestasis and hypoxic liver injury (HLI), and to illustrate its clinical impact on outcome in critically ill patients. RECENT FINDINGS: Liver dysfunction at the intensive care unit can be divided into two main patterns: cholestatic and HLI, also known as ischemic hepatitis or shock liver. Both hepatic dysfunctions occur frequently and early in critical illness. Major issues are the early recognition and subsequent initiation of therapeutic measures. SUMMARY: Clinical awareness of the liver not only as a victim, but also as a trigger of multiorgan failure is of central clinical importance. Physicians have to identify the underlying factors that contribute to its development to initiate curative measures as early as possible.
PURPOSE OF REVIEW: Liver dysfunction frequently complicates the clinical picture of critical illness and leads to increased morbidity and mortality. The purpose of this review is to characterize the most frequent patterns of liver dysfunction at the intensive care unit, cholestasis and hypoxic liver injury (HLI), and to illustrate its clinical impact on outcome in critically illpatients. RECENT FINDINGS:Liver dysfunction at the intensive care unit can be divided into two main patterns: cholestatic and HLI, also known as ischemic hepatitis or shock liver. Both hepatic dysfunctions occur frequently and early in critical illness. Major issues are the early recognition and subsequent initiation of therapeutic measures. SUMMARY: Clinical awareness of the liver not only as a victim, but also as a trigger of multiorgan failure is of central clinical importance. Physicians have to identify the underlying factors that contribute to its development to initiate curative measures as early as possible.
Authors: Marc Jenniskens; Lies Langouche; Yoo-Mee Vanwijngaerden; Dieter Mesotten; Greet Van den Berghe Journal: Intensive Care Med Date: 2015-09-21 Impact factor: 17.440
Authors: Anis Chaari; Karim Abdel Hakim; Kamel Bousselmi; Mahmoud Etman; Mohamed El Bahr; Ahmed El Saka; Eman Hamza; Mohamed Ismail; Elsayed Mahmoud Khalil; Vipin Kauts; William Francis Casey Journal: World J Gastrointest Oncol Date: 2016-07-15
Authors: Su Hwan Lee; Moo Suk Park; Jin Gu Lee; Joo Han Song; Kyung Soo Chung; Ji Ye Jung; Eun Young Kim; Young Sam Kim; Se Kyu Kim; Joon Chang; Hyo Chae Paik; Song Yee Kim Journal: J Thorac Dis Date: 2017-12 Impact factor: 2.895
Authors: James L Weemhoff; Benjamin L Woolbright; Rosalind E Jenkins; Mitchell R McGill; Matthew R Sharpe; Jody C Olson; Daniel J Antoine; Steven C Curry; Hartmut Jaeschke Journal: Liver Int Date: 2016-08-06 Impact factor: 5.828