Literature DB >> 23403250

Aggressive transformation of juvenile myelomonocytic leukemia associated with duplication of oncogenic KRAS due to acquired uniparental disomy.

Motohiro Kato1, Naoko Yasui, Masafumi Seki, Hiroshi Kishimoto, Aiko Sato-Otsubo, Daisuke Hasegawa, Nobutaka Kiyokawa, Ryoji Hanada, Seishi Ogawa, Atsushi Manabe, Junko Takita, Katsuyoshi Koh.   

Abstract

A small fraction of cases of juvenile myelomonocytic leukemia (JMML) develop massive disease activation. Through genomic analysis of JMML, which developed in an individual with mosaicism for oncogenic KRAS mutation with rapid progression, we identified acquired uniparental disomy at 12p. We demonstrated that duplication of oncogenic KRAS is associated with rapid JMML progression.
Copyright © 2013 Mosby, Inc. All rights reserved.

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Year:  2013        PMID： 23403250     DOI： 10.1016/j.jpeds.2013.01.003

Source DB:  PubMed          Journal:  J Pediatr        ISSN： 0022-3476            Impact factor:   4.406


  11 in total

1.  Adults with germline CBL mutation complicated with juvenile myelomonocytic leukemia at infancy.

Authors:  Michiko Muraoka; Chiho Okuma; Kiichiro Kanamitsu; Hisashi Ishida; Yui Kanazawa; Kana Washio; Masafumi Seki; Motohiro Kato; Junko Takita; Yusuke Sato; Seishi Ogawa; Hirokazu Tsukahara; Megumi Oda; Akira Shimada
Journal:  J Hum Genet       Date:  2016-02-25       Impact factor: 3.172

2.  Somatic mosaicism for a NRAS mutation associates with disparate clinical features in RAS-associated leukoproliferative disease: a report of two cases.

Authors:  Mitsutaka Shiota; Xi Yang; Mei Kubokawa; Tatsuya Morishima; Kuniaki Tanaka; Masamitsu Mikami; Kenichi Yoshida; Masako Kikuchi; Kazushi Izawa; Ryuta Nishikomori; Yusuke Okuno; Xian Wang; Hirotoshi Sakaguchi; Hideki Muramatsu; Seiji Kojima; Satoru Miyano; Seishi Ogawa; Masatoshi Takagi; Daisuke Hata; Hirokazu Kanegane
Journal:  J Clin Immunol       Date:  2015-04-21       Impact factor: 8.317

3.  Clinical course of juvenile myelomonocytic leukemia in the blast crisis phase treated by acute myeloid leukemia-oriented chemotherapy and allogeneic hematopoietic stem cell transplantation.

Authors:  Satoshi Ueda; Naoki Sakata; Hideki Muramatsu; Hirotoshi Sakaguchi; Xinan Wang; Yinyan Xu; Seiji Kojima; Toshihiro Yamaguchi; Takeshi Higa; Tsukasa Takemura
Journal:  Int J Hematol       Date:  2014-07-22       Impact factor: 2.490

4.  p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.

Authors:  Jingfang Zhang; Guangyao Kong; Adhithi Rajagopalan; Li Lu; Jingming Song; Mohamed Hussaini; Xinmin Zhang; Erik A Ranheim; Yangang Liu; Jinyong Wang; Xin Gao; Yuan-I Chang; Kirby D Johnson; Yun Zhou; David Yang; Bhavana Bhatnagar; David M Lucas; Emery H Bresnick; Xuehua Zhong; Eric Padron; Jing Zhang
Journal:  Blood       Date:  2016-11-04       Impact factor: 22.113

Review 5.  RAS diseases in children.

Authors:  Charlotte M Niemeyer
Journal:  Haematologica       Date:  2014-11       Impact factor: 9.941

6.  Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.

Authors:  Y-I Chang; X You; G Kong; E A Ranheim; J Wang; J Du; Y Liu; Y Zhou; M-J Ryu; J Zhang
Journal:  Leukemia       Date:  2015-03-24       Impact factor: 11.528

Review 7.  Mutant allele specific imbalance in oncogenes with copy number alterations: Occurrence, mechanisms, and potential clinical implications.

Authors:  Chih-Chieh Yu; Wanglong Qiu; Caroline S Juang; Mahesh M Mansukhani; Balazs Halmos; Gloria H Su
Journal:  Cancer Lett       Date:  2016-10-08       Impact factor: 8.679

8.  Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.

Authors:  Guangyao Kong; Mark Wunderlich; David Yang; Erik A Ranheim; Ken H Young; Jinyong Wang; Yuan-I Chang; Juan Du; Yangang Liu; Sin Ruow Tey; Xinmin Zhang; Mark Juckett; Ryan Mattison; Alisa Damnernsawad; Jingfang Zhang; James C Mulloy; Jing Zhang
Journal:  J Clin Invest       Date:  2014-05-08       Impact factor: 14.808

9.  Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network.

Authors:  Aurélie Caye; Marion Strullu; Fabien Guidez; Bruno Cassinat; Steven Gazal; Odile Fenneteau; Elodie Lainey; Kazem Nouri; Saeideh Nakhaei-Rad; Radovan Dvorsky; Julie Lachenaud; Sabrina Pereira; Jocelyne Vivent; Emmanuelle Verger; Dominique Vidaud; Claire Galambrun; Capucine Picard; Arnaud Petit; Audrey Contet; Marilyne Poirée; Nicolas Sirvent; Françoise Méchinaud; Dalila Adjaoud; Catherine Paillard; Brigitte Nelken; Yves Reguerre; Yves Bertrand; Dieter Häussinger; Jean-Hugues Dalle; Mohammad Reza Ahmadian; André Baruchel; Christine Chomienne; Hélène Cavé
Journal:  Nat Genet       Date:  2015-10-12       Impact factor: 38.330

Review 10.  Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.

Authors:  Cynthia Garcia; David H Gutmann
Journal:  Scientifica (Cairo)       Date:  2014-08-28
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