OBJECTIVE: We investigated occupational risk of multiple myeloma (MM) in a pooled analysis of five international case-control studies. METHODS: We calculated the odds ratio and its 95% confidence interval for selected occupations with unconditional regression analysis in 1959 MM cases and 6192 controls, by pooling study-specific risks using random-effects meta-analysis. Exposure to organic solvents was assessed with a job-exposure matrix (JEM). RESULTS: Gardeners and nursery workers combined, most likely exposed to pesticides, showed a 50% increase in risk (OR = 1.50, 95% CI 0.9-2.3), while other farming jobs did not. Metal processors (OR = 1.55, 95% CI 0.9-2.3), female cleaners (OR = 1.32, 95% CI 1.0-1.8), and high level exposure to organic solvents (OR = 1.38, 95% CI 0.96-1.8) also showed moderately increased risks. CONCLUSIONS: Additional case-control studies of MM aetiology are warranted to further investigate the nature of the repeatedly reported increase in MM risk in several occupational groups.
OBJECTIVE: We investigated occupational risk of multiple myeloma (MM) in a pooled analysis of five international case-control studies. METHODS: We calculated the odds ratio and its 95% confidence interval for selected occupations with unconditional regression analysis in 1959 MM cases and 6192 controls, by pooling study-specific risks using random-effects meta-analysis. Exposure to organic solvents was assessed with a job-exposure matrix (JEM). RESULTS: Gardeners and nursery workers combined, most likely exposed to pesticides, showed a 50% increase in risk (OR = 1.50, 95% CI 0.9-2.3), while other farming jobs did not. Metal processors (OR = 1.55, 95% CI 0.9-2.3), female cleaners (OR = 1.32, 95% CI 1.0-1.8), and high level exposure to organic solvents (OR = 1.38, 95% CI 0.96-1.8) also showed moderately increased risks. CONCLUSIONS: Additional case-control studies of MM aetiology are warranted to further investigate the nature of the repeatedly reported increase in MM risk in several occupational groups.
Authors: Anneclaire J De Roos; John Spinelli; Elizabeth B Brown; Djordje Atanackovic; Dalsu Baris; Leslie Bernstein; Parveen Bhatti; Nicola J Camp; Brian C Chiu; Jacqueline Clavel; Wendy Cozen; Silvia De Sanjosé; James A Dosman; Jonathan N Hofmann; John R McLaughlin; Lucia Miligi; Alain Monnereau; Laurent Orsi; Mark P Purdue; Leah H Schinasi; Guido J Tricot; Sophia S Wang; Yawei Zhang; Brenda M Birmann; Pierluigi Cocco Journal: Occup Environ Med Date: 2018-08-18 Impact factor: 4.948
Authors: Jonathan N Hofmann; Laura E Beane Freeman; Kazunori Murata; Gabriella Andreotti; Joseph J Shearer; Katie Thoren; Lakshmi Ramanathan; Christine G Parks; Stella Koutros; Catherine C Lerro; Danping Liu; Nathaniel Rothman; Charles F Lynch; Barry I Graubard; Dale P Sandler; Michael C Alavanja; Ola Landgren Journal: Environ Health Perspect Date: 2021-01-06 Impact factor: 11.035