OBJECTIVE: To conduct a systematic review, with meta-analysis, of studies assessing the association between night work and the risk of breast cancer, using available epidemiological evidence. METHOD: Relevant studies were identified by searching several databases and the reference lists of retrieved articles. We combined the relative risks (RR) from individual studies using a random-effects model. Subgroup analysis was carried out as the data showed statistically significant heterogeneity. RESULTS: Thirteen studies consisting of eight case-control studies and five cohort studies were included in the analysis. In the combined analysis of all studies, night work was associated with an increased risk for breast cancer (RR = 1.20, 95%CI = 1.08-1.33). The higher-quality studies showed a similar finding with a pooled RR of 1.40 (95%CI = 1.13-1.73). Both case-control studies (RR = 1.32, 95%CI = 1.17-1.50) and cohort studies (RR=1.08, 95%CI = 0.97-1.21) showed a positive association between night work and the risk of breast cancer. No publication bias was found either from Begg's funnel plot (P = 0.086) or the Egger's test (P = 0.107). Additional well-conducted and large-scale epidemiological studies are needed.
OBJECTIVE: To conduct a systematic review, with meta-analysis, of studies assessing the association between night work and the risk of breast cancer, using available epidemiological evidence. METHOD: Relevant studies were identified by searching several databases and the reference lists of retrieved articles. We combined the relative risks (RR) from individual studies using a random-effects model. Subgroup analysis was carried out as the data showed statistically significant heterogeneity. RESULTS: Thirteen studies consisting of eight case-control studies and five cohort studies were included in the analysis. In the combined analysis of all studies, night work was associated with an increased risk for breast cancer (RR = 1.20, 95%CI = 1.08-1.33). The higher-quality studies showed a similar finding with a pooled RR of 1.40 (95%CI = 1.13-1.73). Both case-control studies (RR = 1.32, 95%CI = 1.17-1.50) and cohort studies (RR=1.08, 95%CI = 0.97-1.21) showed a positive association between night work and the risk of breast cancer. No publication bias was found either from Begg's funnel plot (P = 0.086) or the Egger's test (P = 0.107). Additional well-conducted and large-scale epidemiological studies are needed.
Authors: Maryssa Shigesato; Yosuke Kawai; Cherie Guillermo; Fadi Youkhana; Yurii B Shvetsov; Veronica W Setiawan; Christopher A Haiman; Loïc Le Marchand; Gertraud Maskarinec Journal: Int J Cancer Date: 2019-04-10 Impact factor: 7.396
Authors: Chunla He; Sonia Taj Anand; Mark H Ebell; John E Vena; Sara Wagner Robb Journal: Int Arch Occup Environ Health Date: 2014-09-27 Impact factor: 3.015
Authors: Richard G Stevens; George C Brainard; David E Blask; Steven W Lockley; Mario E Motta Journal: CA Cancer J Clin Date: 2013-12-24 Impact factor: 508.702
Authors: Charleen D Adams; Kristina M Jordahl; Wade Copeland; Dana K Mirick; Xiaoling Song; Cassandra L Sather; Karl Kelsey; Andres Houseman; Scott Davis; Timothy Randolph; Parveen Bhatti Journal: Epigenetics Date: 2017-11-27 Impact factor: 4.528