| Literature DB >> 23403082 |
Andrew R Germain1, Leigh C Carmody, Partha P Nag, Barbara Morgan, Lynn Verplank, Cristina Fernandez, Etienne Donckele, Yuxiong Feng, Jose R Perez, Sivaraman Dandapani, Michelle Palmer, Eric S Lander, Piyush B Gupta, Stuart L Schreiber, Benito Munoz.
Abstract
A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations.Entities:
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Year: 2013 PMID： 23403082 DOI： 10.1016/j.bmcl.2013.01.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823