Literature DB >> 23403080

Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives.

Ludovic T Maillard1, Sébastien Bertout, Ophélie Quinonéro, Gülşen Akalin, Gülhan Turan-Zitouni, Pierre Fulcrand, Fatih Demirci, Jean Martinez, Nicolas Masurier.   

Abstract

Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23403080     DOI： 10.1016/j.bmcl.2013.01.039

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles.

Authors:  Adrian L Pietkiewicz; Yuqi Zhang; Marwa N Rahimi; Michael Stramandinoli; Matthew Teusner; Shelli R McAlpine
Journal:  ACS Med Chem Lett       Date:  2017-03-06       Impact factor: 4.345

2.  Synthesis and biological evaluation of (acyl)hydrazones and thiosemicarbazones obtained via in situ condensation of iminium salts with nitrogen-containing nucleophiles.

Authors:  Chiara Caneva; Silvana Alfei; Monica De Maria; Cristina Ibba; Ilenia Delogu; Andrea Spallarossa; Roberta Loddo
Journal:  Mol Divers       Date:  2015-06-16       Impact factor: 3.364

3.  Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.

Authors:  Visesato Mor; Antonella Rella; Amir M Farnoud; Ashutosh Singh; Mansa Munshi; Arielle Bryan; Shamoon Naseem; James B Konopka; Iwao Ojima; Erika Bullesbach; Alan Ashbaugh; Michael J Linke; Melanie Cushion; Margaret Collins; Hari Krishna Ananthula; Larry Sallans; Pankaj B Desai; Nathan P Wiederhold; Annette W Fothergill; William R Kirkpatrick; Thomas Patterson; Lai Hong Wong; Sunita Sinha; Guri Giaever; Corey Nislow; Patrick Flaherty; Xuewen Pan; Gabriele Vargas Cesar; Patricia de Melo Tavares; Susana Frases; Kildare Miranda; Marcio L Rodrigues; Chiara Luberto; Leonardo Nimrichter; Maurizio Del Poeta
Journal:  mBio       Date:  2015-06-23       Impact factor: 7.867

4.  Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) tethered to nano-Fe3O4 as a superior catalyst for the synthesis of 1,3-thiazoles.

Authors:  Hossein Shahbazi-Alavi; Sheida Khojasteh-Khosro; Javad Safaei-Ghomi; Maryam Tavazo
Journal:  BMC Chem       Date:  2019-10-12

Review 5.  A review exploring biological activities of hydrazones.

Authors:  Garima Verma; Akranth Marella; Mohammad Shaquiquzzaman; Mymoona Akhtar; Mohammad Rahmat Ali; Mohammad Mumtaz Alam
Journal:  J Pharm Bioallied Sci       Date:  2014-04

6.  Design and Synthesis of Novel 1,3-Thiazole and 2-Hydrazinyl-1,3-Thiazole Derivatives as Anti-Candida Agents: In Vitro Antifungal Screening, Molecular Docking Study, and Spectroscopic Investigation of their Binding Interaction with Bovine Serum Albumin.

Authors:  Andreea-Iulia Pricopie; Ioana Ionuț; Gabriel Marc; Anca-Maria Arseniu; Laurian Vlase; Adriana Grozav; Luiza Ioana Găină; Dan C Vodnar; Adrian Pîrnău; Brîndușa Tiperciuc; Ovidiu Oniga
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411

Review 7.  Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents.

Authors:  Prisca Lagardère; Cyril Fersing; Nicolas Masurier; Vincent Lisowski
Journal:  Pharmaceuticals (Basel)       Date:  2021-12-27
  7 in total

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