Literature DB >> 23401343

Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).

Junglim Lee1, Deanne W Sammond, Zeno Fiorini, Jonel P Saludes, Michael G Resch, Bing Hao, Wei Wang, Hang Yin, Xuedong Liu.   

Abstract

A structure-based computational approach was used to rationally design peptide inhibitors that can target an E3 ligase (SCF(Fbx4) )-substrate (TRF1) interface and subsequent ubiquitylation. Characterization of the inhibitors demonstrates that our sequence-optimization protocol results in an increase in peptide-TRF1 affinity without compromising peptide-protein specificity.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23401343      PMCID： PMC4028150          DOI： 10.1002/cbic.201200777

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  42 in total

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Review 4.  Helix capping.

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Review 5.  Senescence, apoptosis and therapy--cutting the lifelines of cancer.

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Review 8.  Nucleolar modulation of TRF1: a dynamic way to regulate telomere and cell cycle by nucleostemin and GNL3L.

Authors:  Robert Y L Tsai
Journal:  Cell Cycle       Date:  2009-09-16       Impact factor: 4.534

9.  hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells.

Authors:  J T Chang; Y-C Lu; Y-J Chen; C-P Tseng; Y-L Chen; C-W Fang; A-J Cheng
Journal:  Br J Cancer       Date:  2006-03-27       Impact factor: 7.640

10.  GNL3L stabilizes the TRF1 complex and promotes mitotic transition.

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Journal:  J Cell Biol       Date:  2009-06-01       Impact factor: 10.539
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  2 in total

Review 1.  Recent advances in SCF ubiquitin ligase complex: Clinical implications.

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Journal:  Biochim Biophys Acta       Date:  2016-05-05

2.  Peptiderive server: derive peptide inhibitors from protein-protein interactions.

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Journal:  Nucleic Acids Res       Date:  2016-05-03       Impact factor: 16.971
  2 in total

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