Literature DB >> 23401283

Nonribosomal assembly of natural lipocyclocarbamate lipoprotein-associated phospholipase inhibitors.

Chad W Johnston1, Rostyslav Zvanych, Nadiya Khyzha, Nathan A Magarvey.   

Abstract

EXPANDING OUR KNOWLEDGE: Natural lipocyclocarbamate natural products have provided the inspiration for the first-in-class synthetic phospholipase inhibitor darapladib, currently in phase III clinical trials for the treatment of atherosclerosis. Here, we discuss their biosynthesis by a nonribosomal peptide synthetase.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23401283     DOI： 10.1002/cbic.201200598

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  8 in total

1.  Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in Pseudomonas aeruginosa.

Authors:  Jon B Patteson; Adam R Lescallette; Bo Li
Journal:  Org Lett       Date:  2019-06-25       Impact factor: 6.005

2.  ClpP inhibitors are produced by a widespread family of bacterial gene clusters.

Authors:  Elizabeth J Culp; David Sychantha; Christian Hobson; Andrew C Pawlowski; Gerd Prehna; Gerard D Wright
Journal:  Nat Microbiol       Date:  2022-03-04       Impact factor: 30.964

3.  Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists.

Authors:  Chad W Johnston; Yongchang Li; Nathan A Magarvey
Journal:  Genome Announc       Date:  2016-02-18

4.  Draft Genome Sequence of Cyclic Lipopeptide Producer Pseudomonas sp. Strain SWRI103, Isolated from Wheat Rhizosphere.

Authors:  Samira Zarvandi; Tahereh Bahrami; Brent Pauwels; Ahmad Asgharzadeh; Mehdi Hosseini-Mazinani; Farzaneh Salari; Léa Girard; René De Mot; Hassan Rokni-Zadeh
Journal:  Microbiol Resour Announc       Date:  2020-07-02

5.  Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid.

Authors:  Qing Fang; Linrui Wu; Caroline Urwald; Morgane Mugat; Shan Wang; Kwaku Kyeremeh; Carol Philips; Samantha Law; Yongjun Zhou; Hai Deng
Journal:  Synth Syst Biotechnol       Date:  2021-01-20

6.  Complex peptide natural products: Biosynthetic principles, challenges and opportunities for pathway engineering.

Authors:  Sebastian L Wenski; Sirinthra Thiengmag; Eric J N Helfrich
Journal:  Synth Syst Biotechnol       Date:  2022-02-09

7.  Genome mining and metabolic profiling of the rhizosphere bacterium Pseudomonas sp. SH-C52 for antimicrobial compounds.

Authors:  Menno Van Der Voort; Harold J G Meijer; Yvonne Schmidt; Jeramie Watrous; Ester Dekkers; Rodrigo Mendes; Pieter C Dorrestein; Harald Gross; Jos M Raaijmakers
Journal:  Front Microbiol       Date:  2015-07-07       Impact factor: 5.640

8.  An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products.

Authors:  Chad W Johnston; Michael A Skinnider; Morgan A Wyatt; Xiang Li; Michael R M Ranieri; Lian Yang; David L Zechel; Bin Ma; Nathan A Magarvey
Journal:  Nat Commun       Date:  2015-09-28       Impact factor: 14.919
  8 in total

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