BACKGROUND/ OBJECTIVE: Retinal nerve fiber layer (RNFL) thickness has been linked to brain atrophy in multiple sclerosis (MS). However, little is known about retinal atrophy in 'benign' MS. We compared RNFL thickness in benign MS with healthy controls. METHODS: Patients with benign MS (Expanded Disability Status Scale (EDSS) ≤ 3; ≥15 years' disease duration), identified through the British Columbia MS database, along with age-matched healthy controls, were recruited. RNFL thickness was measured using spectral-domain optical coherence tomography. Analysis of variance (ANOVA) was used to compare groups. The association between RNFL thickness and MS patient characteristics was examined via linear mixed-effects models (adjusting for within-patient inter-eye correlations and history of optic neuritis (ON), where appropriate). RESULTS: Overall, 29 benign MS patients and 29 healthy controls were included, totaling 116 eyes. RNFL thickness was lowest for the benign MS eyes, with and then without a history of ON, followed by healthy controls (mean=73.2 µm, SD ± 0.4; 89.9 µm, SD ± 12.5; 96.7 µm, SD ± 10.4; p<0.02). RNFL thickness was associated with a history of ON (p<0.0001), but not EDSS or disease duration (p>0.1). CONCLUSIONS: RNFL thickness was lower in patients with benign MS than healthy controls, regardless of the previous history of ON. However, no association was found between RNFL values and disability or MS disease duration.
BACKGROUND/ OBJECTIVE: Retinal nerve fiber layer (RNFL) thickness has been linked to brain atrophy in multiple sclerosis (MS). However, little is known about retinal atrophy in 'benign' MS. We compared RNFL thickness in benign MS with healthy controls. METHODS:Patients with benign MS (Expanded Disability Status Scale (EDSS) ≤ 3; ≥15 years' disease duration), identified through the British Columbia MS database, along with age-matched healthy controls, were recruited. RNFL thickness was measured using spectral-domain optical coherence tomography. Analysis of variance (ANOVA) was used to compare groups. The association between RNFL thickness and MS patient characteristics was examined via linear mixed-effects models (adjusting for within-patient inter-eye correlations and history of optic neuritis (ON), where appropriate). RESULTS: Overall, 29 benign MS patients and 29 healthy controls were included, totaling 116 eyes. RNFL thickness was lowest for the benign MS eyes, with and then without a history of ON, followed by healthy controls (mean=73.2 µm, SD ± 0.4; 89.9 µm, SD ± 12.5; 96.7 µm, SD ± 10.4; p<0.02). RNFL thickness was associated with a history of ON (p<0.0001), but not EDSS or disease duration (p>0.1). CONCLUSIONS: RNFL thickness was lower in patients with benign MS than healthy controls, regardless of the previous history of ON. However, no association was found between RNFL values and disability or MS disease duration.
Authors: Praveena Manogaran; James V M Hanson; Elisabeth D Olbert; Christine Egger; Carla Wicki; Christina Gerth-Kahlert; Klara Landau; Sven Schippling Journal: Int J Mol Sci Date: 2016-11-15 Impact factor: 5.923
Authors: Ulrika Birkeldh; Ali Manouchehrinia; Max Albert Hietala; Jan Hillert; Tomas Olsson; Fredrik Piehl; Ingrid Skelton Kockum; Lou Brundin; Ori Zahavi; Marika Wahlberg-Ramsay; Rune Brautaset; Maria Nilsson Journal: Front Neurol Date: 2017-12-13 Impact factor: 4.003
Authors: Rachel C Nolan; Steven L Galetta; Teresa C Frohman; Elliot M Frohman; Peter A Calabresi; Carmen Castrillo-Viguera; Diego Cadavid; Laura J Balcer Journal: J Neuroophthalmol Date: 2018-12 Impact factor: 3.042
Authors: Fahmy Aboulenein-Djamshidian; Martin Krššák; Nermin Serbecic; Helmut Rauschka; Sven Beutelspacher; Ivica Just Kukurová; Ladislav Valkovič; Adnan Khan; Daniela Prayer; Wolfgang Kristoferitsch Journal: PLoS One Date: 2015-11-13 Impact factor: 3.240