| Literature DB >> 23400472 |
Monica Red Brewer1, William Pao.
Abstract
Investigators report the identification of novel mutant-specific inhibition of EGF receptor (EGFR) T790M by bis-indole-based inhibitors of protein kinase C using a small-molecule cancer cell line-based screening platform. This study shows the power of high-throughput drug screening in cancer cell lines and provides new lead scaffolds for optimization against resistant EGFR mutants in lung cancer.Entities:
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Year: 2013 PMID： 23400472 DOI： 10.1158/2159-8290.CD-12-0581
Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397