| Literature DB >> 23399934 |
Liu Qi1, He Hongjuan, Gu Ning, Han Zhengbin, Xing Yanjiang, Zeng Tiebo, Huang Zhijun, Wu Qiong.
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development.Entities:
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Year: 2013 PMID： 23399934 DOI： 10.1016/j.febslet.2013.01.070
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124