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Literature DB >> 23399643

Neurodegenerative disease: altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease.

Heather Wood.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2013 PMID： 23399643 DOI： 10.1038/nrneurol.2013.23

Source DB: PubMed Journal: Nat Rev Neurol ISSN： 1759-4758 Impact factor: 42.937

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3 in total

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Authors:
Journal: Cell Date: 1993-03-26 Impact factor: 41.582

2. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.

Authors: Kirupa Sathasivam; Andreas Neueder; Theresa A Gipson; Christian Landles; Agnesska C Benjamin; Marie K Bondulich; Donna L Smith; Richard L M Faull; Raymund A C Roos; David Howland; Peter J Detloff; David E Housman; Gillian P Bates
Journal: Proc Natl Acad Sci U S A Date: 2013-01-22 Impact factor: 11.205

3. Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

Authors: Christopher W Ng; Ferah Yildirim; Yoon Sing Yap; Simona Dalin; Bryan J Matthews; Patricio J Velez; Adam Labadorf; David E Housman; Ernest Fraenkel
Journal: Proc Natl Acad Sci U S A Date: 2013-01-22 Impact factor: 11.205

3 in total

5 in total

Review 5. DNA Methylation: A Promising Approach in Management of Alzheimer's Disease and Other Neurodegenerative Disorders.

Authors: Gagandeep Kaur; Suraj Singh S Rathod; Mohammed M Ghoneim; Sultan Alshehri; Javed Ahmad; Awanish Mishra; Nabil A Alhakamy
Journal: Biology (Basel) Date: 2022-01-07

5 in total

Neurodegenerative disease: altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease.

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

2. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.

3. Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

Review 1. Epigenetic mechanisms of neurodegeneration in Huntington's disease.

Review 2. Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders.

Review 3. Epigenomic Remodeling in Huntington's Disease-Master or Servant?

4. DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients.

Review 5. DNA Methylation: A Promising Approach in Management of Alzheimer's Disease and Other Neurodegenerative Disorders.