Literature DB >> 23399597

Love and death: microglia, NLRP3 and the Alzheimer's brain.

Tobias Goldmann1, Tuan Leng Tay, Marco Prinz.   

Abstract

Microglia were previously attributed to be vital brain guardians for neuronal survival and synaptic pruning during development as well as for the brain's fight against environmental pathogens. A new report in Nature by the Heneka, Latz and Golenbock groups, however, sheds new light on these distinct myeloid cells by revealing their deadly nature for mature neurons during neurodegeneration.

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Year:  2013        PMID： 23399597      PMCID： PMC3641594          DOI： 10.1038/cr.2013.24

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain.

Authors:  F Alliot; I Godin; B Pessac
Journal:  Brain Res Dev Brain Res       Date:  1999-11-18

Review 2.  Heterogeneity of CNS myeloid cells and their roles in neurodegeneration.

Authors:  Marco Prinz; Josef Priller; Sangram S Sisodia; Richard M Ransohoff
Journal:  Nat Neurosci       Date:  2011-09-27       Impact factor: 24.884

Review 3.  Microglia in the CNS: immigrants from another world.

Authors:  Marco Prinz; Alexander Mildner
Journal:  Glia       Date:  2011-02       Impact factor: 7.452

4.  Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.

Authors:  Katrin Kierdorf; Daniel Erny; Tobias Goldmann; Victor Sander; Christian Schulz; Elisa Gomez Perdiguero; Peter Wieghofer; Annette Heinrich; Pia Riemke; Christoph Hölscher; Dominik N Müller; Bruno Luckow; Thomas Brocker; Katharina Debowski; Günter Fritz; Ghislain Opdenakker; Andreas Diefenbach; Knut Biber; Mathias Heikenwalder; Frederic Geissmann; Frank Rosenbauer; Marco Prinz
Journal:  Nat Neurosci       Date:  2013-01-20       Impact factor: 24.884

5.  Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome.

Authors:  H M Hoffman; J L Mueller; D H Broide; A A Wanderer; R D Kolodner
Journal:  Nat Genet       Date:  2001-11       Impact factor: 38.330

6.  Fate mapping analysis reveals that adult microglia derive from primitive macrophages.

Authors:  Florent Ginhoux; Melanie Greter; Marylene Leboeuf; Sayan Nandi; Peter See; Solen Gokhan; Mark F Mehler; Simon J Conway; Lai Guan Ng; E Richard Stanley; Igor M Samokhvalov; Miriam Merad
Journal:  Science       Date:  2010-10-21       Impact factor: 47.728

Review 7.  The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.

Authors:  Luigi Franchi; Tatjana Eigenbrod; Raúl Muñoz-Planillo; Gabriel Nuñez
Journal:  Nat Immunol       Date:  2009-03       Impact factor: 25.606

8.  The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.

Authors:  Annett Halle; Veit Hornung; Gabor C Petzold; Cameron R Stewart; Brian G Monks; Thomas Reinheckel; Katherine A Fitzgerald; Eicke Latz; Kathryn J Moore; Douglas T Golenbock
Journal:  Nat Immunol       Date:  2008-07-11       Impact factor: 25.606

9.  A lineage of myeloid cells independent of Myb and hematopoietic stem cells.

Authors:  Christian Schulz; Elisa Gomez Perdiguero; Laurent Chorro; Heather Szabo-Rogers; Nicolas Cagnard; Katrin Kierdorf; Marco Prinz; Bishan Wu; Sten Eirik W Jacobsen; Jeffrey W Pollard; Jon Frampton; Karen J Liu; Frederic Geissmann
Journal:  Science       Date:  2012-03-22       Impact factor: 47.728

10.  NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.

Authors:  Michael T Heneka; Markus P Kummer; Andrea Stutz; Andrea Delekate; Stephanie Schwartz; Ana Vieira-Saecker; Angelika Griep; Daisy Axt; Anita Remus; Te-Chen Tzeng; Ellen Gelpi; Annett Halle; Martin Korte; Eicke Latz; Douglas T Golenbock
Journal:  Nature       Date:  2012-12-19       Impact factor: 49.962
  10 in total
  19 in total

1.  Spatial Training Ameliorates Long-Term Alzheimer's Disease-Like Pathological Deficits by Reducing NLRP3 Inflammasomes in PR5 Mice.

Authors:  Qing-Guo Ren; Wei-Gang Gong; Hong Zhou; Hao Shu; Yan-Juan Wang; Zhi-Jun Zhang
Journal:  Neurotherapeutics       Date:  2019-04       Impact factor: 7.620

2.  A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice.

Authors:  Bogale Aredo; Tao Li; Xiao Chen; Kaiyan Zhang; Cynthia Xin-Zhao Wang; Darlene Gou; Biren Zhao; Yuguang He; Rafael L Ufret-Vincenty
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-06       Impact factor: 4.799

Review 3.  Inflammatory Profiles of the Interleukin Family and Network in Cerebral Hemorrhage.

Authors:  Lei Ye; Lu Gao; Hongwei Cheng
Journal:  Cell Mol Neurobiol       Date:  2018-07-19       Impact factor: 5.046

Review 4.  The role of innate immunity in Alzheimer's disease.

Authors:  Hannah E Ennerfelt; John R Lukens
Journal:  Immunol Rev       Date:  2020-06-26       Impact factor: 12.988

5.  Functional microglia derived from human pluripotent stem cells empower retinal organ.

Authors:  Mei-Ling Gao; Xiao Zhang; Fang Han; Jia Xu; Si-Jian Yu; Kangxin Jin; Zi-Bing Jin
Journal:  Sci China Life Sci       Date:  2022-04-22       Impact factor: 10.372

Review 6.  NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

Authors:  Evan A Bordt; Brian M Polster
Journal:  Free Radic Biol Med       Date:  2014-08-01       Impact factor: 7.376

7.  NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH.

Authors:  Sheng-Tao Yao; Fang Cao; Jia-Lin Chen; Wei Chen; Rui-Ming Fan; Gang Li; You-Chao Zeng; Song Jiao; Xiang-Ping Xia; Chong Han; Qi-Shan Ran
Journal:  J Mol Neurosci       Date:  2016-12-08       Impact factor: 3.444

8.  P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy.

Authors:  Huan Wang; Ling-Juan Hong; Ji-Yun Huang; Quan Jiang; Rong-Rong Tao; Chao Tan; Nan-Nan Lu; Cheng-Kun Wang; Muhammad M Ahmed; Ying-Mei Lu; Zhi-Rong Liu; Wei-Xing Shi; En-Yin Lai; Christopher S Wilcox; Feng Han
Journal:  Cell Res       Date:  2015-05-22       Impact factor: 25.617

Review 9.  Nutritional and Nanotechnological Modulators of Microglia.

Authors:  Dusica Maysinger; Issan Zhang
Journal:  Front Immunol       Date:  2016-07-15       Impact factor: 7.561

Review 10.  Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease.

Authors:  Yidan Zhang; Yuan Zhao; Jian Zhang; Guofeng Yang
Journal:  Neurochem Res       Date:  2020-09-14       Impact factor: 3.996
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