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Literature DB >> 23399550

Glycoprotein disease markers and single protein-omics.

Abstract

Glycoproteins are well represented among biomarkers for inflammatory and cancer diseases. Secreted and membrane-associated glycoproteins make excellent targets for noninvasive detection. In this review, we discuss clinically applicable markers of cancer diseases and methods for their analysis. High throughput discovery continues to supply marker candidates with unusual glycan structures, altered glycoprotein abundance, or distribution of site-specific glycoforms. Improved analytical methods are needed to unlock the potential of these discoveries in validated clinical assays. A new generation of targeted quantitative assays is expected to advance the use of glycoproteins in early detection of diseases, molecular disease classification, and monitoring of therapeutic interventions.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2013 PMID： 23399550 PMCID： PMC3617330 DOI： 10.1074/mcp.R112.026930

Source DB: PubMed Journal: Mol Cell Proteomics ISSN： 1535-9476 Impact factor: 5.911

111 in total

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Journal: Glycobiology Date: 2008-08-13 Impact factor: 4.313

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Journal: Rapid Commun Mass Spectrom Date: 2008-09 Impact factor: 2.419

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15 in total

Review 1. Solving glycosylation disorders: fundamental approaches reveal complicated pathways.

Authors: Hudson H Freeze; Jessica X Chong; Michael J Bamshad; Bobby G Ng
Journal: Am J Hum Genet Date: 2014-02-06 Impact factor: 11.025

2. Site-specific analysis of changes in the glycosylation of proteins in liver cirrhosis using data-independent workflow with soft fragmentation.

Authors: Miloslav Sanda; Lihua Zhang; Nathan J Edwards; Radoslav Goldman
Journal: Anal Bioanal Chem Date: 2016-11-07 Impact factor: 4.142

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Authors: Miloslav Sanda; Radoslav Goldman
Journal: Anal Chem Date: 2016-09-29 Impact factor: 6.986

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Authors: Radoslav Goldman; Miloslav Sanda
Journal: Proteomics Clin Appl Date: 2015-01-19 Impact factor: 3.494

5. Serum N-glycan analysis in breast cancer patients--Relation to tumour biology and clinical outcome.

Authors: Vilde D Haakensen; Israel Steinfeld; Radka Saldova; Akram Asadi Shehni; Ilona Kifer; Bjørn Naume; Pauline M Rudd; Anne-Lise Børresen-Dale; Zohar Yakhini
Journal: Mol Oncol Date: 2015-08-19 Impact factor: 6.603

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Authors: Emil Paleček; Jan Tkáč; Martin Bartošík; Tomáš Bertók; Veronika Ostatná; Jan Paleček
Journal: Chem Rev Date: 2015-02-09 Impact factor: 60.622

7. The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

Authors: Agostino Bruno; Mario Scrima; Ettore Novellino; Gerardino D'Errico; Anna Maria D'Ursi; Vittorio Limongelli
Journal: Sci Rep Date: 2015-03-17 Impact factor: 4.379