Literature DB >> 23399226

Spectroscopic investigation on the inclusion complex formation between amisulpride and γ-cyclodextrin.

Jeetendra Singh Negi1, Shivpal Singh.   

Abstract

The purpose of this research was to investigate inclusion complex formation between poorly soluble drug amisulpride (AMI) and γ-cyclodextrin (γ-CD). The solubility of AMI was enhanced by formation of inclusion complex of AMI with nano-hydrophobic cavity of γ-CD. The stoichiometry of inclusion complex was studied by continuous variation Job's plot method and found 1:1. The binding constant was found 1166.65 M(-1) by Benesi-Hildebrand plot. The molecular docking of AMI and γ-CD was done to investigate complexation. The inclusion complex formation was further confirmed by (1)H NMR and FT-IR, DSC and XRD analysis. The solubility of AMI was increased 3.74 times after inclusion complex formation with γ-CD.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23399226     DOI： 10.1016/j.carbpol.2012.11.082

Source DB:  PubMed          Journal:  Carbohydr Polym        ISSN： 0144-8617            Impact factor:   9.381


  6 in total

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Authors:  Supachai Songngam; Mongkol Sukwattanasinitt; Krisana Siralertmukul; Pattara Sawasdee
Journal:  AAPS PharmSciTech       Date:  2014-05-31       Impact factor: 3.246

2.  Study to Probe Subsistence of Host-Guest Inclusion Complexes of α and β-Cyclodextrins with Biologically Potent Drugs for Safety Regulatory Dischargement.

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Journal:  Sci Rep       Date:  2018-08-29       Impact factor: 4.379

3.  Cinnamaldehyde-cucurbituril complex: investigation of loading efficiency and its role in enhancing cinnamaldehyde in vitro anti-tumor activity.

Authors:  Bayan Al Tbakhi; Hamdi Nsairat; Walhan Alshaer; Abdulfattah Al-Kadash; Wissam Helal; Lubna Alrawashdeh; Anthony Day; Khaleel I Assaf; Rola Hassouneh; Fadwa Odeh; Abeer Al Bawab
Journal:  RSC Adv       Date:  2022-03-08       Impact factor: 3.361

4.  Preparation, characterization, and biological activity study of thymoquinone-cucurbit[7]uril inclusion complex.

Authors:  Lubna Alrawashdeh; Khaleel I Assaf; Walhan Alshaer; Fadwa Odeh; Suhair A Bani-Atta
Journal:  RSC Adv       Date:  2022-01-12       Impact factor: 3.361

5.  Remote loading of curcumin-in-modified β-cyclodextrins into liposomes using a transmembrane pH gradient.

Authors:  Fadwa Odeh; Hamdi Nsairat; Walhan Alshaer; Shrouq Alsotari; Rula Buqaien; Said Ismail; Abdalla Awidi; Abeer Al Bawab
Journal:  RSC Adv       Date:  2019-11-13       Impact factor: 4.036

6.  Improvement of the Solubility and Evaluation of the Physical Properties of an Inclusion Complex Formed by a New Ferulic Acid Derivative and γ-Cyclodextrin.

Authors:  Nao Ikeda; Yutaka Inoue; Yuka Ogata; Isamu Murata; Xuan Meiyan; Jun Takayama; Takeshi Sakamoto; Mari Okazaki; Ikuo Kanamoto
Journal:  ACS Omega       Date:  2020-05-18
  6 in total

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