Literature DB >> 23397508

Hijacking of Basic Research: The Case of Synthetic Cannabinoids.

Jenny L Wiley1, Julie A Marusich, John W Huffman, Robert L Balster, Brian F Thomas.   

Abstract

Gathering and communicating knowledge are important aspects of the scientific endeavor. Yet presentation of data in public forums such as scientific meetings and publications makes it available not only to scientists, but also to others who may have different ideas about how to use research findings. A recent example of this type of hijacking is the introduction of synthetic cannabinoids that are sprayed on herbal products and subsequently smoked for their marijuana-like intoxicating properties. Originally developed for the legitimate research purpose of furthering understanding of the cannabinoid system, these synthetic cannabinoids are being abused worldwide, creating issues for regulatory and law enforcement agencies that are struggling to keep up with the growing number of compounds of various structural motifs. Basic and clinical scientists need to provide advice now to facilitate decision-making about the health threats posed by this emerging problem.

Entities:  

Year:  2011        PMID: 23397508      PMCID: PMC3567606          DOI: 10.3768/rtipress.2011.op.0007.1111

Source DB:  PubMed          Journal:  Methods Rep RTI Press


  32 in total

1.  The pharmacology of 1-(1-phenylcyclohexyl) piperidine-HCl.

Authors:  G CHEN; C R ENSOR; D RUSSELL; B BOHNER
Journal:  J Pharmacol Exp Ther       Date:  1959-11       Impact factor: 4.030

2.  Pharmacology of pravadoline: a new analgesic agent.

Authors:  D R Haubrich; S J Ward; E Baizman; M R Bell; J Bradford; R Ferrari; M Miller; M Perrone; A K Pierson; J K Saelens
Journal:  J Pharmacol Exp Ther       Date:  1990-11       Impact factor: 4.030

Review 3.  Cannabinoid CB(2) receptors in health and disease.

Authors:  Kamala D Patel; Joseph S Davison; Quentin J Pittman; Keith A Sharkey
Journal:  Curr Med Chem       Date:  2010       Impact factor: 4.530

4.  Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes.

Authors:  G Griffin; P J Atkinson; V M Showalter; B R Martin; M E Abood
Journal:  J Pharmacol Exp Ther       Date:  1998-05       Impact factor: 4.030

5.  Chemical analysis of synthetic cannabinoids as designer drugs in herbal products.

Authors:  Nahoko Uchiyama; Ruri Kikura-Hanajiri; Jun Ogata; Yukihiro Goda
Journal:  Forensic Sci Int       Date:  2010-05-20       Impact factor: 2.395

6.  Nephrotoxicity of pravadoline maleate (WIN 48098-6) in dogs: evidence of maleic acid-induced acute tubular necrosis.

Authors:  R M Everett; G Descotes; M Rollin; Y Greener; J C Bradford; D P Benziger; S J Ward
Journal:  Fundam Appl Toxicol       Date:  1993-07

7.  Use of SPME-HS-GC-MS for the analysis of herbal products containing synthetic cannabinoids.

Authors:  Anderson O Cox; Richard C Daw; Michele D Mason; Megan Grabenauer; Poonam G Pande; Kenneth H Davis; Jenny L Wiley; Peter R Stout; Brian F Thomas; John W Huffman
Journal:  J Anal Toxicol       Date:  2012-06       Impact factor: 3.367

8.  Aminoalkylindoles: structure-activity relationships of novel cannabinoid mimetics.

Authors:  M A Eissenstat; M R Bell; T E D'Ambra; E J Alexander; S J Daum; J H Ackerman; M D Gruett; V Kumar; K G Estep; E M Olefirowicz
Journal:  J Med Chem       Date:  1995-08-04       Impact factor: 7.446

9.  Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys.

Authors:  J L Wiley; J A Lowe; R L Balster; B R Martin
Journal:  J Pharmacol Exp Ther       Date:  1995-10       Impact factor: 4.030

10.  Withdrawal phenomena and dependence syndrome after the consumption of "spice gold".

Authors:  Ulrich S Zimmermann; Patricia R Winkelmann; Max Pilhatsch; Josef A Nees; Rainer Spanagel; Katja Schulz
Journal:  Dtsch Arztebl Int       Date:  2009-07-03       Impact factor: 5.594

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  15 in total

Review 1.  "Herbal incense": designer drug blends as cannabimimetics and their assessment by drug discrimination and other in vivo bioassays.

Authors:  Torbjörn U C Järbe; Roger S Gifford
Journal:  Life Sci       Date:  2013-07-25       Impact factor: 5.037

Review 2.  Baths salts, spice, and related designer drugs: the science behind the headlines.

Authors:  Michael H Baumann; Ernesto Solis; Lucas R Watterson; Julie A Marusich; William E Fantegrossi; Jenny L Wiley
Journal:  J Neurosci       Date:  2014-11-12       Impact factor: 6.167

Review 3.  Pharmacological and Toxicological Effects of Synthetic Cannabinoids and Their Metabolites.

Authors:  Sherrica Tai; William E Fantegrossi
Journal:  Curr Top Behav Neurosci       Date:  2017

4.  Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS.

Authors:  Adarsh S Gandhi; Mingshe Zhu; Shaokun Pang; Ariane Wohlfarth; Karl B Scheidweiler; Marilyn A Huestis
Journal:  Bioanalysis       Date:  2014-06       Impact factor: 2.681

5.  Neurocognition and subjective experience following acute doses of the synthetic cannabinoid JWH-018: a phase 1, placebo-controlled, pilot study.

Authors:  Eef L Theunissen; Nadia R P W Hutten; Natasha L Mason; Stefan W Toennes; Kim P C Kuypers; Eliza B de Sousa Fernandes Perna; Johannes G Ramaekers
Journal:  Br J Pharmacol       Date:  2017-11-29       Impact factor: 8.739

6.  Synthetic Cannabinoid Hydroxypentyl Metabolites Retain Efficacy at Human Cannabinoid Receptors.

Authors:  Thomas F Gamage; Charlotte E Farquhar; Ryan J McKinnie; Richard C Kevin; Iain S McGregor; Mark L Trudell; Jenny L Wiley; Brian F Thomas
Journal:  J Pharmacol Exp Ther       Date:  2018-12-14       Impact factor: 4.030

7.  Molecular and Behavioral Pharmacological Characterization of Abused Synthetic Cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-Fluoro-CUMYL-PICA.

Authors:  Thomas F Gamage; Charlotte E Farquhar; Timothy W Lefever; Julie A Marusich; Richard C Kevin; Iain S McGregor; Jenny L Wiley; Brian F Thomas
Journal:  J Pharmacol Exp Ther       Date:  2018-03-16       Impact factor: 4.030

8.  In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018.

Authors:  Thomas F Gamage; Daniel G Barrus; Richard C Kevin; David B Finlay; Timothy W Lefever; Purvi R Patel; Megan A Grabenauer; Michelle Glass; Iain S McGregor; Jenny L Wiley; Brian F Thomas
Journal:  Pharmacol Biochem Behav       Date:  2020-04-02       Impact factor: 3.533

9.  Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation.

Authors:  Rachelle Abouchedid; James H Ho; Simon Hudson; Alison Dines; John R H Archer; David M Wood; Paul I Dargan
Journal:  J Med Toxicol       Date:  2016-07-25

Review 10.  Marijuana, Spice 'herbal high', and early neural development: implications for rescheduling and legalization.

Authors:  Delphine Psychoyos; K Yaragudri Vinod
Journal:  Drug Test Anal       Date:  2012-08-13       Impact factor: 3.345

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