Temporal trends in characteristics and outcome of intensive care unit patients with systemic lupus erythematosus in Taiwan: a national population-based study.

This study assessed temporal trends in characteristics and outcome of the intensive care unit (ICU) patients with systemic lupus erythematosus (SLE). We analyzed 2870 SLE patients (≥15 years) with first-time ICU admission between 1999 and 2008. Patient data were retrieved from the Taiwan National Health Insurance Research Database. Median age of the patients increased from 38.5 to 44.0 years during the study period. Most patients were women (overall 85.5%); the proportion varied insignificantly over time. Median duration from SLE diagnosis to ICU admission (disease duration) increased by four years. The proportion of patients with disease duration of more than three years increased from 42.6% to 61.4%, whereas the proportion of patients with a primary rheumatic diagnosis decreased from 41.7% to 25.1%. The incidence of infection increased from 39.1% to 47.2%. The incidence of organ dysfunction increased from 64.1% to 69.2%, especially in neurological, cardiovascular, and respiratory systems. Conversely, the incidence of renal dysfunction decreased from 36.2% to 28.8%. Meanwhile, there were decreasing uses of hemodialysis (from 37.3% to 28.7%) and vasopressors (from 58.3% to 47.9%). Hospital mortality also decreased from 42.6% to 31.2% during the 10 years. After the patient and hospital characteristics were adjusted, patients admitted in 2007 and 2008 were 50% less likely to die than those admitted in 1999 and 2000 (adjusted odds ratio 0.5, 95% confidence interval 0.38-0.67). This study demonstrates a temporal improvement of the short-term survival of the ICU patients with SLE in Taiwan despite changing characteristics and increasing severity of the acute critical illnesses.