BACKGROUND/AIMS: The variable number of tandem repeats (VNTR) in the last exon of the carboxyl-ester lipase (CEL) gene has been reported to associate with alcohol-induced chronic pancreatitis (ACP) in a Japanese study. Here, we have investigated the association between the number of CEL VNTR repeats and ACP or idiopathic chronic pancreatitis (ICP) in a cohort of German patients. METHODS: Patients diagnosed with ACP (n = 203) or ICP (n = 64) were genotyped using a screening method consisting of PCR followed by DNA fragment analysis. The allele frequencies of different CEL VNTR lengths were compared to the frequencies in healthy controls (n = 390). RESULTS: We observed no statistical significant associations between CEL VNTR allele frequencies and ACP or ICP. CONCLUSION: This study did not find evidence that supported an association between the common length variations of the CEL VNTR and chronic pancreatitis.
BACKGROUND/AIMS: The variable number of tandem repeats (VNTR) in the last exon of the carboxyl-ester lipase (CEL) gene has been reported to associate with alcohol-induced chronic pancreatitis (ACP) in a Japanese study. Here, we have investigated the association between the number of CEL VNTR repeats and ACP or idiopathic chronic pancreatitis (ICP) in a cohort of German patients. METHODS:Patients diagnosed with ACP (n = 203) or ICP (n = 64) were genotyped using a screening method consisting of PCR followed by DNA fragment analysis. The allele frequencies of different CEL VNTR lengths were compared to the frequencies in healthy controls (n = 390). RESULTS: We observed no statistical significant associations between CEL VNTR allele frequencies and ACP or ICP. CONCLUSION: This study did not find evidence that supported an association between the common length variations of the CEL VNTR and chronic pancreatitis.
Authors: Matthew J Giefer; Mark E Lowe; Steven L Werlin; Bridget Zimmerman; Michael Wilschanski; David Troendle; Sarah Jane Schwarzenberg; John F Pohl; Joseph Palermo; Chee Y Ooi; Veronique D Morinville; Tom K Lin; Sohail Z Husain; Ryan Himes; Melvin B Heyman; Tanja Gonska; Cheryl E Gariepy; Steven D Freedman; Douglas S Fishman; Melena D Bellin; Bradley Barth; Maisam Abu-El-Haija; Aliye Uc Journal: J Pediatr Date: 2017-05-10 Impact factor: 4.406
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Authors: Xunjun Xiao; Gabrielle Jones; Wednesday A Sevilla; Donna B Stolz; Kelsey E Magee; Margaret Haughney; Amitava Mukherjee; Yan Wang; Mark E Lowe Journal: J Biol Chem Date: 2016-09-20 Impact factor: 5.157
Authors: Soma Kumar; Chee Y Ooi; Steven Werlin; Maisam Abu-El-Haija; Bradley Barth; Melena D Bellin; Peter R Durie; Douglas S Fishman; Steven D Freedman; Cheryl Gariepy; Matthew J Giefer; Tanja Gonska; Melvin B Heyman; Ryan Himes; Sohail Z Husain; Tom K Lin; Mark E Lowe; Veronique Morinville; Joseph J Palermo; John F Pohl; Sarah Jane Schwarzenberg; David Troendle; Michael Wilschanski; M Bridget Zimmerman; Aliye Uc Journal: JAMA Pediatr Date: 2016-06-01 Impact factor: 16.193