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Literature DB >> 23395165

The Hunger Games: p53 regulates metabolism upon serine starvation.

Abstract

Cancer cells reprogram their metabolism to support a high proliferative rate. A new study shows that, upon serine starvation, the tumor suppressor p53 activates p21 to shift metabolic flux from purine biosynthesis to glutathione production, which enhances cellular proliferation and viability by combating ROS (Maddocks et al., 2013).

Entities: Chemical Disease Gene Species

Year: 2013 PMID： 23395165 PMCID： PMC3634368 DOI： 10.1016/j.cmet.2013.01.012

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

9 in total

Review 1. p53 regulation of metabolic pathways.

Authors: Eyal Gottlieb; Karen H Vousden
Journal: Cold Spring Harb Perspect Biol Date: 2009-12-02 Impact factor: 10.005

2. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Authors: Jason W Locasale; Alexandra R Grassian; Tamar Melman; Costas A Lyssiotis; Katherine R Mattaini; Adam J Bass; Gregory Heffron; Christian M Metallo; Taru Muranen; Hadar Sharfi; Atsuo T Sasaki; Dimitrios Anastasiou; Edouard Mullarky; Natalie I Vokes; Mika Sasaki; Rameen Beroukhim; Gregory Stephanopoulos; Azra H Ligon; Matthew Meyerson; Andrea L Richardson; Lynda Chin; Gerhard Wagner; John M Asara; Joan S Brugge; Lewis C Cantley; Matthew G Vander Heiden
Journal: Nat Genet Date: 2011-07-31 Impact factor: 38.330

Review 3. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.

Authors: Patrick S Ward; Craig B Thompson
Journal: Cancer Cell Date: 2012-03-20 Impact factor: 31.743

4. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.

Authors: Tongyuan Li; Ning Kon; Le Jiang; Minjia Tan; Thomas Ludwig; Yingming Zhao; Richard Baer; Wei Gu
Journal: Cell Date: 2012-06-08 Impact factor: 41.582

5. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

Authors: S P Linke; K C Clarkin; A Di Leonardo; A Tsou; G M Wahl
Journal: Genes Dev Date: 1996-04-15 Impact factor: 11.361

Review 6. Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authors: Matthew G Vander Heiden; Lewis C Cantley; Craig B Thompson
Journal: Science Date: 2009-05-22 Impact factor: 47.728

Review 7. Hallmarks of cancer: the next generation.

Authors: Douglas Hanahan; Robert A Weinberg
Journal: Cell Date: 2011-03-04 Impact factor: 41.582

8. Serine is a natural ligand and allosteric activator of pyruvate kinase M2.

Authors: Barbara Chaneton; Petra Hillmann; Liang Zheng; Agnès C L Martin; Oliver D K Maddocks; Achuthanunni Chokkathukalam; Joseph E Coyle; Andris Jankevics; Finn P Holding; Karen H Vousden; Christian Frezza; Marc O'Reilly; Eyal Gottlieb
Journal: Nature Date: 2012-10-14 Impact factor: 49.962

9. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Authors: Oliver D K Maddocks; Celia R Berkers; Susan M Mason; Liang Zheng; Karen Blyth; Eyal Gottlieb; Karen H Vousden
Journal: Nature Date: 2012-12-16 Impact factor: 49.962

9 in total

Review 1. Targeting amino acid metabolism in cancer growth and anti-tumor immune response.

Authors: Elitsa Ananieva
Journal: World J Biol Chem Date: 2015-11-26

Review 2. Serine, glycine and one-carbon units: cancer metabolism in full circle.

Authors: Jason W Locasale
Journal: Nat Rev Cancer Date: 2013-07-04 Impact factor: 60.716

3. Metagenomics approach to the study of the gut microbiome structure and function in zebrafish Danio rerio fed with gluten formulated diet.

Authors: Hyunmin Koo; Joseph A Hakim; Mickie L Powell; Ranjit Kumar; Peter G Eipers; Casey D Morrow; Michael Crowley; Elliot J Lefkowitz; Stephen A Watts; Asim K Bej
Journal: J Microbiol Methods Date: 2017-02-03 Impact factor: 2.363

4. cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

Authors: Linchong Sun; Libing Song; Qianfen Wan; Gongwei Wu; Xinghua Li; Yinghui Wang; Jin Wang; Zhaoji Liu; Xiuying Zhong; Xiaoping He; Shengqi Shen; Xin Pan; Ailing Li; Yulan Wang; Ping Gao; Huiru Tang; Huafeng Zhang
Journal: Cell Res Date: 2015-03-20 Impact factor: 25.617

5. Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function.

Authors: Jia Shen; Xiangpeng Sheng; Zenan Chang; Qian Wu; Sheng Wang; Zongliang Xuan; Dan Li; Yalan Wu; Yongjia Shang; Xiangtao Kong; Long Yu; Lin Li; Kangchen Ruan; Hongyu Hu; Ying Huang; Lijian Hui; Dong Xie; Fudi Wang; Ronggui Hu
Journal: Cell Rep Date: 2014-03-27 Impact factor: 9.423