Literature DB >> 23395164

TCF7L2 and diabetes: a tale of two tissues, and of two species.

Mark I McCarthy1, Patrik Rorsman, Anna L Gloyn.   

Abstract

Human genetics is revealing ever more variants that influence propensity to common diseases, but progress in translating these discoveries into the biological mechanisms responsible for predisposition continues to lag behind. A recent paper in Cell (Boj et al., 2012) using rodent models to examine how diabetes-associated variants near TCF7L2 perturb metabolic regulation provides surprising results.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23395164     DOI： 10.1016/j.cmet.2013.01.011

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  14 in total

1.  Bridging the gap between genetic associations and molecular mechanisms for type 2 diabetes.

Authors:  Hui Jin Ng; Anna L Gloyn
Journal:  Curr Diab Rep       Date:  2013-12       Impact factor: 4.810

2.  TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR.

Authors:  Tao Zhang; Bofang Wang; Fei Su; Baohong Gu; Lin Xiang; Lei Gao; Peng Zheng; Xue-Mei Li; Hao Chen
Journal:  Int J Biol Sci       Date:  2022-07-11       Impact factor: 10.750

3.  Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility.

Authors:  Ashis K Mondal; Neeraj K Sharma; Steven C Elbein; Swapan K Das
Journal:  Physiol Genomics       Date:  2013-05-14       Impact factor: 3.107

Review 4.  Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility.

Authors:  Swapan Kumar Das; Neeraj Kumar Sharma
Journal:  World J Diabetes       Date:  2014-04-15

5.  Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.

Authors:  Anubha Mahajan; Daniel Taliun; Matthias Thurner; Neil R Robertson; Jason M Torres; N William Rayner; Anthony J Payne; Valgerdur Steinthorsdottir; Robert A Scott; Niels Grarup; James P Cook; Ellen M Schmidt; Matthias Wuttke; Chloé Sarnowski; Reedik Mägi; Jana Nano; Christian Gieger; Stella Trompet; Cécile Lecoeur; Michael H Preuss; Bram Peter Prins; Xiuqing Guo; Lawrence F Bielak; Jennifer E Below; Donald W Bowden; John Campbell Chambers; Young Jin Kim; Maggie C Y Ng; Lauren E Petty; Xueling Sim; Weihua Zhang; Amanda J Bennett; Jette Bork-Jensen; Chad M Brummett; Mickaël Canouil; Kai-Uwe Ec Kardt; Krista Fischer; Sharon L R Kardia; Florian Kronenberg; Kristi Läll; Ching-Ti Liu; Adam E Locke; Jian'an Luan; Ioanna Ntalla; Vibe Nylander; Sebastian Schönherr; Claudia Schurmann; Loïc Yengo; Erwin P Bottinger; Ivan Brandslund; Cramer Christensen; George Dedoussis; Jose C Florez; Ian Ford; Oscar H Franco; Timothy M Frayling; Vilmantas Giedraitis; Sophie Hackinger; Andrew T Hattersley; Christian Herder; M Arfan Ikram; Martin Ingelsson; Marit E Jørgensen; Torben Jørgensen; Jennifer Kriebel; Johanna Kuusisto; Symen Ligthart; Cecilia M Lindgren; Allan Linneberg; Valeriya Lyssenko; Vasiliki Mamakou; Thomas Meitinger; Karen L Mohlke; Andrew D Morris; Girish Nadkarni; James S Pankow; Annette Peters; Naveed Sattar; Alena Stančáková; Konstantin Strauch; Kent D Taylor; Barbara Thorand; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Jaakko Tuomilehto; Daniel R Witte; Josée Dupuis; Patricia A Peyser; Eleftheria Zeggini; Ruth J F Loos; Philippe Froguel; Erik Ingelsson; Lars Lind; Leif Groop; Markku Laakso; Francis S Collins; J Wouter Jukema; Colin N A Palmer; Harald Grallert; Andres Metspalu; Abbas Dehghan; Anna Köttgen; Goncalo R Abecasis; James B Meigs; Jerome I Rotter; Jonathan Marchini; Oluf Pedersen; Torben Hansen; Claudia Langenberg; Nicholas J Wareham; Kari Stefansson; Anna L Gloyn; Andrew P Morris; Michael Boehnke; Mark I McCarthy
Journal:  Nat Genet       Date:  2018-10-08       Impact factor: 38.330

6.  Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities.

Authors:  Carlo de Lorenzo; Annalisa Greco; Teresa Vanessa Fiorentino; Gaia Chiara Mannino; Marta Letizia Hribal
Journal:  Int J Genomics       Date:  2013-05-23       Impact factor: 2.326

7.  Genetic determinants for gestational diabetes mellitus and related metabolic traits in Mexican women.

Authors:  Alicia Huerta-Chagoya; Paola Vázquez-Cárdenas; Hortensia Moreno-Macías; Leonardo Tapia-Maruri; Rosario Rodríguez-Guillén; Erika López-Vite; Guadalupe García-Escalante; Fernando Escobedo-Aguirre; Adalberto Parra-Covarrubias; Roberto Cordero-Brieño; Lizette Manzo-Carrillo; Rogelio Zacarías-Castillo; Carlos Vargas-García; Carlos Aguilar-Salinas; Teresa Tusié-Luna
Journal:  PLoS One       Date:  2015-05-14       Impact factor: 3.240

8.  Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.

Authors:  Robert Wagner; Jia Li; Erhan Kenar; Oliver Kohlbacher; Fausto Machicao; Hans-Ulrich Häring; Andreas Fritsche; Guowang Xu; Rainer Lehmann
Journal:  Sci Rep       Date:  2014-06-13       Impact factor: 4.379

9.  Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

Authors:  Ryan K Mitchell; Angeles Mondragon; Lingling Chen; James A Mcginty; Paul M French; Jorge Ferrer; Bernard Thorens; David J Hodson; Guy A Rutter; Gabriela Da Silva Xavier
Journal:  Hum Mol Genet       Date:  2014-10-29       Impact factor: 6.150

10.  Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway.

Authors:  D D Yao; L Yang; Y Wang; C Liu; Y J Wei; X B Jia; W Yin; L Shu
Journal:  Cell Death Dis       Date:  2015-05-07       Impact factor: 8.469
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