| Literature DB >> 23394318 |
Lin Yang1, Lirui Qiao, Chengxue Ji, Dan Xie, Ning-Bo Gong, Yang Lu, Jianjun Zhang, Jungui Dai, Shunxing Guo.
Abstract
Ten new abietane diterpenoids, aquilarabietic acids A-J (1-10), and a new podocarpane diterpenoid, aquilarabietic acid K (11), were isolated from the petroleum ether and ethanol extracts of Chinese eaglewood. Among them, 3, 9, and 10 are artifacts. Their structures were established on the basis of data from extensive spectroscopic and X-ray diffraction analyses. Bioassay results indicated that 1 at 10 μM demonstrated remarkable antidepressant activity in vitro by inhibiting norepinephrine reuptake in rat brain synaptosomes by 81.4% and with an IC(50) value of 9.1 × 10(-7) M.Entities:
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Year: 2013 PMID： 23394318 DOI： 10.1021/np3006925
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050