Tamar Tzur1, Eyal Sheiner. 1. Department of Obstetrics & Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. tzort@bgu.ac.il
Abstract
OBJECTIVE: To examine whether an association exists between platelet (PLT) count in the first trimester of pregnancy and the risk for hypertensive disorders or other obstetric complications. METHODS: The study population included all registered births with available PLT count from the first trimester of pregnancy during 2000-2010. Thrombocytopenia was defined as PLT count below 100,000/μL. A comparison was performed between women with and without thrombocytopenia. Multiple logistic regression models were used to control for confounders. RESULTS: The study population included 33,890 deliveries; of these, 119 (0.35%) were with thrombocytopenia. Women with thrombocytopenia had significantly higher rates of preterm delivery (16.0% vs. 9.4%; p = 0.015). There was no significant difference between the groups regarding hypertensive disorders. CONCLUSIONS: Hypertensive disorders cannot be predicted based on PLT count during the first trimester of pregnancy. Nevertheless, thrombocytopenia during the first trimester is a risk factor for preterm delivery.
OBJECTIVE: To examine whether an association exists between platelet (PLT) count in the first trimester of pregnancy and the risk for hypertensive disorders or other obstetric complications. METHODS: The study population included all registered births with available PLT count from the first trimester of pregnancy during 2000-2010. Thrombocytopenia was defined as PLT count below 100,000/μL. A comparison was performed between women with and without thrombocytopenia. Multiple logistic regression models were used to control for confounders. RESULTS: The study population included 33,890 deliveries; of these, 119 (0.35%) were with thrombocytopenia. Women with thrombocytopenia had significantly higher rates of preterm delivery (16.0% vs. 9.4%; p = 0.015). There was no significant difference between the groups regarding hypertensive disorders. CONCLUSIONS:Hypertensive disorders cannot be predicted based on PLT count during the first trimester of pregnancy. Nevertheless, thrombocytopenia during the first trimester is a risk factor for preterm delivery.
Authors: Santiago Garcia-Tizon Larroca; Juan Arevalo-Serrano; Virginia Ortega Abad; Pilar Pintado Recarte; Alejandro Garcia Carreras; Gonzalo Nozaleda Pastor; Cesar Rodriguez Hernandez; Ricardo Perez Fernandez Pacheco; Juan De Leon Luis Journal: Open Access Maced J Med Sci Date: 2017-02-01