Literature DB >> 23394066

Synthesis of optically pure 2-trifluoromethyl lactic acid by asymmetric hydroformylation.

Xiao Wang1, Stephen L Buchwald.   

Abstract

By utilizing Rh catalysts ligated by the P-chirogenic ligands QuinoxP* and DuanPhos, 3,3,3-trifluoroprop-1-en-2-yl acetate could be hydroformylated and subsequently oxidized to yield enantiomerically pure 2-trifluoromethyllactic acid.

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Year:  2013        PMID： 23394066     DOI： 10.1021/jo400115r

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Enantioselective Synthesis of 4-Methyl-3,4-dihydroisocoumarin via Asymmetric Hydroformylation of Styrene Derivatives.

Authors:  Bo Qu; Renchang Tan; Madison R Herling; Nizar Haddad; Nelu Grinberg; Marisa C Kozlowski; Xumu Zhang; Chris H Senanayake
Journal:  J Org Chem       Date:  2019-03-06       Impact factor: 4.354

2.  α-Tetrasubstituted Aldehydes through Electronic and Strain-Controlled Branch-Selective Stereoselective Hydroformylation.

Authors:  Josephine Eshon; Floriana Foarta; Clark R Landis; Jennifer M Schomaker
Journal:  J Org Chem       Date:  2018-08-17       Impact factor: 4.354

3.  Construction of a quaternary stereogenic center by asymmetric hydroformylation: a straightforward method to prepare chiral α-quaternary amino acids.

Authors:  Dequan Zhang; Jialin Wen; Xumu Zhang
Journal:  Chem Sci       Date:  2022-06-06       Impact factor: 9.969
  3 in total

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