Literature DB >> 23392901

Stage-dependent anti-allodynic effects of intrathecal Toll-like receptor 4 antagonists in a rat model of cancer induced bone pain.

Xiu Li1, Xiao-Wei Wang, Xiao-Ming Feng, Wen-Jun Zhou, Yan-Qing Wang, Qi-Liang Mao-Ying.   

Abstract

It has been reported that Toll-like receptor 4 (TLR4), which plays an important role in glial activation in neuropathic pain, is significantly increased in cancer pain. The present study was designed to assess the role of TLR4 in cancer-induced bone pain (CIBP) by intrathecal administration of TLR4 signaling pathway blocker naloxone or lipopolysaccharide Rhodobacter sphaeroides (LPS-RS). The rats developed significant mechanical allodynia from day 8 after intratibial Walker 256 inoculation. Intrathecal injection of naloxone or LPS-RS at day 8 significantly attenuated mechanical allodynia as shown by increased paw withdrawal thresholds. In contrast, the same pharmacological treatment showed no or slight pain relieving effect at day 16. Our findings demonstrate that the spinal TLR4 signaling pathway contributes to the mechanism underlying CIBP in a stage-dependent manner in rats, and it may be an efficacious target at early stage for the treatment in the future.

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Year:  2013        PMID： 23392901     DOI： 10.1007/s12576-012-0244-5

Source DB:  PubMed          Journal:  J Physiol Sci        ISSN： 1880-6546            Impact factor:   2.781


  31 in total

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Journal:  Nat Rev Cancer       Date:  2002-03       Impact factor: 60.716

2.  Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain.

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3.  Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains.

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Journal:  Brain Behav Immun       Date:  2011-04-03       Impact factor: 7.217

4.  The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy.

Authors:  Flobert Y Tanga; Nancy Nutile-McMenemy; Joyce A DeLeo
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-04       Impact factor: 11.205

5.  Combined systemic administration of the glycine/NMDA receptor antagonist, (+)-HA966 and morphine attenuates pain-related behaviour in a rat model of trigeminal neuropathic pain.

Authors:  Dennis Christensen; Michèle Gautron; Gisèle Guilbaud; Valérie Kayser
Journal:  Pain       Date:  1999-12       Impact factor: 6.961

6.  Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components.

Authors:  N Laflamme; S Rivest
Journal:  FASEB J       Date:  2001-01       Impact factor: 5.191

7.  Different tumors in bone each give rise to a distinct pattern of skeletal destruction, bone cancer-related pain behaviors and neurochemical changes in the central nervous system.

Authors:  Mary Ann C Sabino; Nancy M Luger; David B Mach; Scott D Rogers; Matthew J Schwei; Patrick W Mantyh
Journal:  Int J Cancer       Date:  2003-05-01       Impact factor: 7.396

8.  Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain.

Authors:  F Y Tanga; V Raghavendra; J A DeLeo
Journal:  Neurochem Int       Date:  2004 Jul-Aug       Impact factor: 3.921

9.  Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism.

Authors:  Hee Young Kim; Jigong Wang; Inhyung Lee; Hee Kee Kim; Kyungsoon Chung; Jin Mo Chung
Journal:  Pain       Date:  2009-07-30       Impact factor: 6.961

10.  Evidence that opioids may have toll-like receptor 4 and MD-2 effects.

Authors:  Mark R Hutchinson; Yingning Zhang; Mitesh Shridhar; John H Evans; Madison M Buchanan; Tina X Zhao; Peter F Slivka; Benjamen D Coats; Niloofar Rezvani; Julie Wieseler; Travis S Hughes; Kyle E Landgraf; Stefanie Chan; Stephanie Fong; Simon Phipps; Joseph J Falke; Leslie A Leinwand; Steven F Maier; Hang Yin; Kenner C Rice; Linda R Watkins
Journal:  Brain Behav Immun       Date:  2009-08-11       Impact factor: 7.217
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  13 in total

1.  Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphine.

Authors:  Lori N Eidson; Anne Z Murphy
Journal:  J Neurosci       Date:  2013-10-02       Impact factor: 6.167

Review 2.  The neurobiology of cancer pain.

Authors:  Brian L Schmidt
Journal:  Neuroscientist       Date:  2014-03-24       Impact factor: 7.519

3.  Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.

Authors:  Andrew J Kwilasz; Suzanne M Green Fulgham; Julissa Chante Duran-Malle; Anouk E W Schrama; Eric H Mitten; Laurel S Todd; Hardik P Patel; Tracey A Larson; Madison A Clements; Kevin M Harris; Scott T Litwiler; Lewis O Harvey; Steven F Maier; Raymond A Chavez; Kenner C Rice; Anne-Marie Van Dam; Linda R Watkins
Journal:  Brain Behav Immun       Date:  2021-01-07       Impact factor: 7.217

4.  Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.

Authors:  Ann M Gregus; Matthew W Buczynski; Darren S Dumlao; Paul C Norris; Ganesha Rai; Anton Simeonov; David J Maloney; Ajit Jadhav; Qinghao Xu; Spencer C Wei; Bethany L Fitzsimmons; Edward A Dennis; Tony L Yaksh
Journal:  Pain       Date:  2018-12       Impact factor: 7.926

5.  Intrathecal injection of lentivirus-mediated glial cell line-derived neurotrophic factor RNA interference relieves bone cancer-induced pain in rats.

Authors:  Fu-Fen Meng; Yang Xu; Qi-Qin Dan; La Wei; Ying-Jie Deng; Jia Liu; Mu He; Wei Liu; Qing-Jie Xia; Fiona H Zhou; Ting-Hua Wang; Xi-Yan Wang
Journal:  Cancer Sci       Date:  2015-04-07       Impact factor: 6.716

6.  Palliation of bone cancer pain by antagonists of platelet-activating factor receptors.

Authors:  Katsuya Morita; Seiji Shiraishi; Naoyo Motoyama; Tomoya Kitayama; Takashi Kanematsu; Yasuhito Uezono; Toshihiro Dohi
Journal:  PLoS One       Date:  2014-03-17       Impact factor: 3.240

7.  Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta.

Authors:  Xisheng Yan; Enshe Jiang; Han-Rong Weng
Journal:  J Neuroinflammation       Date:  2015-01-09       Impact factor: 8.322

8.  Paclitaxel induces acute pain via directly activating toll like receptor 4.

Authors:  Xisheng Yan; Dylan W Maixner; Ruchi Yadav; Mei Gao; Pei Li; Michael G Bartlett; Han-Rong Weng
Journal:  Mol Pain       Date:  2015-03-11       Impact factor: 3.395

Review 9.  Current studies of acupuncture in cancer-induced bone pain animal models.

Authors:  Hee Kyoung Ryu; Yong-Hyeon Baek; Yeon-Cheol Park; Byung-Kwan Seo
Journal:  Evid Based Complement Alternat Med       Date:  2014-10-14       Impact factor: 2.629

10.  Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model.

Authors:  Agnieszka M Jurga; Ewelina Rojewska; Anna Piotrowska; Wioletta Makuch; Dominika Pilat; Barbara Przewlocka; Joanna Mika
Journal:  Neural Plast       Date:  2015-12-29       Impact factor: 3.599
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