OBJECTIVE: To test the hypothesis that transfusion of leukocyte-depleted RBC preparations within the first 48 hours of PICU stay was independently associated with prolonged duration of mechanical ventilation, irrespective of surgery type and disease severity. DESIGN: Retrospective, observational study. SETTING: Single-center PICU in The Netherlands. PATIENTS: Children less than 18 years consecutively admitted after pediatric cardiac surgery between February 2007 and February 2010. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Data from 335 patients were used for analysis of whom 86 (25.7%) were transfused during the first 48 hours of PICU stay. Duration of mechanical ventilation (115 ± 19 hours vs. 25 ± 4 hours, p < 0.001) was longer among transfused patients. Ventilator-associated pneumonia (10.5% vs. 1.6%, odds ratio 7.2; 95% confidence interval 1.92-32.47; p < 0.001) was more frequent among transfused patients. New acute kidney injury after 48 hours of PICU admission (23.9% vs. 15.4%, p = 0.18) and mortality were comparable (2.3% vs. 4%, p = 0.16). The number of discrete transfusion events was significantly correlated with the duration of mechanical ventilation (Spearman's rho 0.617, p < 0.001). Transfusion remained independently associated with prolonged duration of mechanical ventilation after adjusting for confounders using Cox proportional hazards regression analysis. CONCLUSIONS: Transfusion of leukocyte-depleted RBCs within the first 48 hours of PICU stay after cardiac surgery is independently associated with prolonged duration of mechanical ventilation.
OBJECTIVE: To test the hypothesis that transfusion of leukocyte-depleted RBC preparations within the first 48 hours of PICU stay was independently associated with prolonged duration of mechanical ventilation, irrespective of surgery type and disease severity. DESIGN: Retrospective, observational study. SETTING: Single-center PICU in The Netherlands. PATIENTS: Children less than 18 years consecutively admitted after pediatric cardiac surgery between February 2007 and February 2010. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Data from 335 patients were used for analysis of whom 86 (25.7%) were transfused during the first 48 hours of PICU stay. Duration of mechanical ventilation (115 ± 19 hours vs. 25 ± 4 hours, p < 0.001) was longer among transfused patients. Ventilator-associated pneumonia (10.5% vs. 1.6%, odds ratio 7.2; 95% confidence interval 1.92-32.47; p < 0.001) was more frequent among transfused patients. New acute kidney injury after 48 hours of PICU admission (23.9% vs. 15.4%, p = 0.18) and mortality were comparable (2.3% vs. 4%, p = 0.16). The number of discrete transfusion events was significantly correlated with the duration of mechanical ventilation (Spearman's rho 0.617, p < 0.001). Transfusion remained independently associated with prolonged duration of mechanical ventilation after adjusting for confounders using Cox proportional hazards regression analysis. CONCLUSIONS: Transfusion of leukocyte-depleted RBCs within the first 48 hours of PICU stay after cardiac surgery is independently associated with prolonged duration of mechanical ventilation.
Authors: Pierre Demaret; Guillaume Emeriaud; Nabil E Hassan; Martin C J Kneyber; Stacey L Valentine; Scot T Bateman; Marisa Tucci Journal: Pediatr Crit Care Med Date: 2018-09 Impact factor: 3.624
Authors: Jill M Cholette; Ariane Willems; Stacey L Valentine; Scot T Bateman; Steven M Schwartz Journal: Pediatr Crit Care Med Date: 2018-09 Impact factor: 3.624
Authors: Faisal Matto; Peter C Kouretas; Richard Smith; Jacob Ostrowsky; Anthony J Cina; Douglas T Hess; Jonathan S Stamler; James D Reynolds Journal: Clin Transl Sci Date: 2017-12-12 Impact factor: 4.689
Authors: Jennifer A Muszynski; Philip C Spinella; Jill M Cholette; Jason P Acker; Mark W Hall; Nicole P Juffermans; Daniel P Kelly; Neil Blumberg; Kathleen Nicol; Jennifer Liedel; Allan Doctor; Kenneth E Remy; Marisa Tucci; Jacques Lacroix; Philip J Norris Journal: Transfusion Date: 2016-10-02 Impact factor: 3.157
Authors: Felina K Mille; Aditya Badheka; Priscilla Yu; Xuemei Zhang; David F Friedman; John Kheir; Sarah van den Bosch; Antonio G Cabrera; Javier J Lasa; Hannah Katcoff; Paula Hu; Santiago Borasino; Krissie Hock; Jordan Huskey; Jamie Weller; Harsh Kothari; Joshua Blinder Journal: J Am Heart Assoc Date: 2020-05-11 Impact factor: 5.501