AIM: To identify disease-related risk factors for an altered bone mineral density (BMD) and geometry at young adulthood in patients with diabetes mellitus type 1 (DM1). METHODS: Fifty-six DM1 patients (23 females, 33 males) with prepubertal onset of diabetes were studied after completion of skeletal growth. Bone parameters at the distal radius were investigated by peripheral quantitative computed tomography. Disease-related parameters, in particular average HbA1c during the 2 years around peak height velocity, were analyzed. Forty-seven healthy controls (32 females, 15 males) were studied. RESULTS: Trabecular BMD was similar between DM1 patients and controls. The mean (±SD) cross-sectional bone area (CSA) was smaller in DM1 patients compared to controls (282.5 ± 45.4 vs. 326.7 ± 52.2 mm(2), p = 0.002 and males 391.0 ± 61.3 vs. 423.4 ± 81.9 mm(2), p = 0.1). In female DM1 patients, the CSA z-score correlated negatively with the body mass index z-score (r = -0.52, p = 0.01) and positively with the height z-score (r = 0.49, p = 0.02). CONCLUSIONS: DM1 patients are at risk for smaller bone sizes at the distal radius at the end of pubertal growth, especially females with increased adiposity. Diabetes-specific parameters seem to have a low impact on forearm volumetric apparent mineral density.
AIM: To identify disease-related risk factors for an altered bone mineral density (BMD) and geometry at young adulthood in patients with diabetes mellitus type 1 (DM1). METHODS: Fifty-six DM1 patients (23 females, 33 males) with prepubertal onset of diabetes were studied after completion of skeletal growth. Bone parameters at the distal radius were investigated by peripheral quantitative computed tomography. Disease-related parameters, in particular average HbA1c during the 2 years around peak height velocity, were analyzed. Forty-seven healthy controls (32 females, 15 males) were studied. RESULTS: Trabecular BMD was similar between DM1 patients and controls. The mean (±SD) cross-sectional bone area (CSA) was smaller in DM1 patients compared to controls (282.5 ± 45.4 vs. 326.7 ± 52.2 mm(2), p = 0.002 and males 391.0 ± 61.3 vs. 423.4 ± 81.9 mm(2), p = 0.1). In female DM1 patients, the CSA z-score correlated negatively with the body mass index z-score (r = -0.52, p = 0.01) and positively with the height z-score (r = 0.49, p = 0.02). CONCLUSIONS: DM1 patients are at risk for smaller bone sizes at the distal radius at the end of pubertal growth, especially females with increased adiposity. Diabetes-specific parameters seem to have a low impact on forearm volumetric apparent mineral density.
Authors: Eleanor P Thong; Madhuni Herath; David R Weber; Sanjeeva Ranasinha; Peter R Ebeling; Frances Milat; Helena Teede Journal: Clin Endocrinol (Oxf) Date: 2018-07-03 Impact factor: 3.478
Authors: David R Weber; Rebecca J Gordon; Jennifer C Kelley; Mary B Leonard; Steven M Willi; Jacquelyn Hatch-Stein; Andrea Kelly; Oksana Kosacci; Olena Kucheruk; Mirna Kaafarani; Babette S Zemel Journal: J Clin Endocrinol Metab Date: 2019-10-01 Impact factor: 5.958
Authors: V V Zhukouskaya; C Eller-Vainicher; A P Shepelkevich; Y Dydyshko; E Cairoli; I Chiodini Journal: J Endocrinol Invest Date: 2015-04-12 Impact factor: 4.256