| Literature DB >> 23391762 |
Shuai Zhang1, Changliang Shan, Wenjing Cui, Xiaona You, Yumei Du, Guangyao Kong, Fabao Gao, Lihong Ye, Xiaodong Zhang.
Abstract
The involvement of hepatitis B virus X protein (HBx) in anti-complement-dependent cytotoxicity (CDC) activity during hepatocarcinogenesis is poorly understood. Here, we report that HBx is able to up-regulate membrane-bound complement regulatory protein CD46 in hepatoma cells and human immortalized liver cells through activating the promoter activity involving cAMP response element-binding protein (CREB)/cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway. In contrast, the down-regulation of CD46 abolishes the resistance capability of hepatoma cells to CDC. Thus, we conclude that HBx contributes to the protection of hepatoma and hepatic cells from CDC by up-regulation of CD46.Entities:
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Year: 2013 PMID： 23391762 DOI： 10.1016/j.febslet.2013.01.019
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124