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Literature DB >> 23391241

Central leucine sensing in the control of energy homeostasis.

Abstract

This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem. Activation of these leucine sensing sites engages multiple determinants of energy balance, including glucose homeostasis, food intake, and adiposity.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Leucine

Year: 2012 PMID： 23391241 PMCID： PMC3568262 DOI： 10.1016/j.ecl.2012.12.001

Source DB: PubMed Journal: Endocrinol Metab Clin North Am ISSN： 0889-8529 Impact factor: 4.741

18 in total

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Authors: Gary J Schwartz
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Review 4. Brainstem mechanisms integrating gut-derived satiety signals and descending forebrain information in the control of meal size.

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6. Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis.

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Journal: Cell Metab Date: 2009-04 Impact factor: 27.287

8. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit.

Authors: Clémence Blouet; Young-Hwan Jo; Xiaosong Li; Gary J Schwartz
Journal: J Neurosci Date: 2009-07-01 Impact factor: 6.167

9. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats.

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Journal: J Clin Invest Date: 2008-08 Impact factor: 14.808

10. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms.

Authors: Yiying Zhang; Kaiying Guo; Robert E LeBlanc; Daniella Loh; Gary J Schwartz; Yi-Hao Yu
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Review 4. Interactions in the Metabolism of Glutamate and the Branched-Chain Amino Acids and Ketoacids in the CNS.

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Review 7. Hormonal regulation of the hypothalamic melanocortin system.

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Journal: Front Physiol Date: 2014-12-09 Impact factor: 4.566

8. A human leucyl-tRNA synthetase as an anticancer target.

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Review 10. Emerging Evidence for the Importance of Dietary Protein Source on Glucoregulatory Markers and Type 2 Diabetes: Different Effects of Dairy, Meat, Fish, Egg, and Plant Protein Foods.

Authors: Kevin B Comerford; Gonca Pasin
Journal: Nutrients Date: 2016-07-23 Impact factor: 5.717