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Literature DB >> 23391237

Defective counterregulation and hypoglycemia unawareness in diabetes: mechanisms and emerging treatments.

Candace M Reno¹, Marina Litvin, Amy L Clark, Simon J Fisher.

Abstract

For people with diabetes, hypoglycemia remains the limiting factor in achieving glycemic control. This article reviews recent advances in how the brain senses and responds to hypoglycemia. Novel mechanisms by which individuals with insulin-treated diabetes develop hypoglycemia unawareness and impaired counterregulatory responses are outlined. Prevention strategies for reducing the incidence of hypoglycemia are discussed.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Glucagon

Year: 2012 PMID： 23391237 PMCID： PMC3568263 DOI： 10.1016/j.ecl.2012.11.005

Source DB: PubMed Journal: Endocrinol Metab Clin North Am ISSN： 0889-8529 Impact factor: 4.741

122 in total

Review 1. Efficacy of continuous glucose monitoring in improving glycemic control and reducing hypoglycemia: a systematic review and meta-analysis of randomized trials.

Authors: Gunjan Y Gandhi; Michelle Kovalaske; Yogish Kudva; Kristin Walsh; Mohamed B Elamin; Melody Beers; Cathy Coyle; Melissa Goalen; Mohammad Safwan Murad; Patricia J Erwin; Joshua Corpus; Victor M Montori; M Hassan Murad
Journal: J Diabetes Sci Technol Date: 2011-07-01

2. Hypoglycemia anticipation, awareness and treatment training (HAATT) reduces occurrence of severe hypoglycemia among adults with type 1 diabetes mellitus.

Authors: Daniel J Cox; Boris Kovatchev; Dragomir Koev; Lidia Koeva; Svetoslav Dachev; Dimitar Tcharaktchiev; Anastassia Protopopova; Linda Gonder-Frederick; William Clarke
Journal: Int J Behav Med Date: 2004

3. Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia.

Authors: Jason W Mastaitis; Elisa Wurmbach; Hui Cheng; Stuart C Sealfon; Charles V Mobbs
Journal: Diabetes Date: 2005-04 Impact factor: 9.461

4. Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness.

Authors: Gülin Öz; Nolawit Tesfaye; Anjali Kumar; Dinesh K Deelchand; Lynn E Eberly; Elizabeth R Seaquist
Journal: J Cereb Blood Flow Metab Date: 2011-10-05 Impact factor: 6.200

Review 5. Recovery of endocrine function after islet and pancreas transplantation.

Authors: Michael R Rickels
Journal: Curr Diab Rep Date: 2012-10 Impact factor: 4.810

6. Hypoglycemia and the sympathoadrenal system: neurogenic symptoms are largely the result of sympathetic neural, rather than adrenomedullary, activation.

Authors: Michael A DeRosa; Philip E Cryer
Journal: Am J Physiol Endocrinol Metab Date: 2004-02-17 Impact factor: 4.310

7. Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia.

Authors: Kelly A Diggs-Andrews; Xuezhao Zhang; Zhentao Song; Dorit Daphna-Iken; Vanessa H Routh; Simon J Fisher
Journal: Diabetes Date: 2010-06-14 Impact factor: 9.461

8. Unexplained deaths of type 1 diabetic patients.

Authors: R B Tattersall; G V Gill
Journal: Diabet Med Date: 1991-01 Impact factor: 4.359

9. Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration.

Authors:
Journal: Diabetologia Date: 2007-04-06 Impact factor: 10.122

10. Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration.

Authors: Raimund I Herzog; Owen Chan; Sunkyung Yu; James Dziura; Ewan C McNay; Robert S Sherwin
Journal: Endocrinology Date: 2008-01-10 Impact factor: 4.736

16 in total

Review 1. Mechanisms of hypoglycemia unawareness and implications in diabetic patients.

Authors: Iciar Martín-Timón; Francisco Javier Del Cañizo-Gómez
Journal: World J Diabetes Date: 2015-07-10

2. Recurrent hypoglycemia: boosting the brain's metabolic flexibility.

Authors: Marina Litvin; Amy L Clark; Simon J Fisher
Journal: J Clin Invest Date: 2013-04-01 Impact factor: 14.808

Review 3. Current therapeutic approaches in the management of hyperglycemia in chronic renal disease.

Authors: Vishnu Garla; Licy Yanes-Cardozo; Lillian F Lien
Journal: Rev Endocr Metab Disord Date: 2017-03 Impact factor: 6.514

Review 4. Hypoglycemia in patients with type 1 diabetes: epidemiology, pathogenesis, and prevention.

Authors: Omodele Awoniyi; Rabia Rehman; Samuel Dagogo-Jack
Journal: Curr Diab Rep Date: 2013-10 Impact factor: 4.810

5. Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells.

Authors: Mollisa M Elrick; Willis K Samson; John A Corbett; Alison S Salvatori; Lauren M Stein; Grant R Kolar; Aaron Naatz; Gina L C Yosten
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2015-11-11 Impact factor: 3.619

6. Leptin acts in the brain to influence hypoglycemic counterregulation: disparate effects of acute and recurrent hypoglycemia on glucagon release.

Authors: Candace M Reno; Yuyan Ding; Robert Sherwin
Journal: Am J Physiol Endocrinol Metab Date: 2015-10-27 Impact factor: 4.310