AIMS AND BACKGROUND: Based on estrogen receptor (ER), progesterone receptor (PgR) and Her2/neu (HER2) expression, four breast cancer subtypes have been distinguished: luminal A (ER and/or PgR/HER2-, Ki67 <14%), luminal B (ER and/or PgR/HER2-, Ki67 ≥14% or ER and/or PgR/HER2), triple-negative (ER-/PgR-/HER2-), and HER2 (ER-/PgR-/HER2). Our aim was to evaluate the prognosis of these phenotypes in the pre-trastuzumab era in a large cohort of Italian women. METHODS AND STUDY DESIGN: We studied 2347 breast cancer patients, in stage I-II, registered by the Modena Cancer Registry from 1999 to 2006 in the Modena province, Italy. Overall survival, disease-free survival and second non-mammary tumors were evaluated. RESULTS: A total of 1868 luminal A (79.6%), 195 luminal B (8.3%), 205 triple-negative (8.7%) and 79 HER2 (3.4%) patients were identified. A better prognosis was observed for luminal A than for luminal B, HER2 and triple-negative subtypes (5-year overall survival, 91% vs 89% vs 87% vs 86%, respectively, P <0.001). Disease-free survival for pT1a and pT1b tumors was worse in HER2 (82%) than in triple-negative (90%), luminal B (95%) and luminal A (97%) (P = 0.013). Finally, luminal B patients had a significantly higher rate of second non-mammary tumors than the other groups. CONCLUSIONS: In the pre-trastuzumab era, luminal A patients showed a better 5-year overall survival than luminal B, HER2 and triple-negative patients, but in terms of disease-free survival, HER2 subtype represented an unfavorable group over time, whereas the triple-negative group had an increased risk of relapse in the first 42 months and then decreased. Among each prognostic factor, ER <10%, Ki67 >14% and HER2 overexpression are considered as risk factors, but only HER2 positivity seems to preserve the role over time.
AIMS AND BACKGROUND: Based on estrogen receptor (ER), progesterone receptor (PgR) and Her2/neu (HER2) expression, four breast cancer subtypes have been distinguished: luminal A (ER and/or PgR/HER2-, Ki67 <14%), luminal B (ER and/or PgR/HER2-, Ki67 ≥14% or ER and/or PgR/HER2), triple-negative (ER-/PgR-/HER2-), and HER2 (ER-/PgR-/HER2). Our aim was to evaluate the prognosis of these phenotypes in the pre-trastuzumab era in a large cohort of Italian women. METHODS AND STUDY DESIGN: We studied 2347 breast cancer patients, in stage I-II, registered by the Modena Cancer Registry from 1999 to 2006 in the Modena province, Italy. Overall survival, disease-free survival and second non-mammary tumors were evaluated. RESULTS: A total of 1868 luminal A (79.6%), 195 luminal B (8.3%), 205 triple-negative (8.7%) and 79 HER2 (3.4%) patients were identified. A better prognosis was observed for luminal A than for luminal B, HER2 and triple-negative subtypes (5-year overall survival, 91% vs 89% vs 87% vs 86%, respectively, P <0.001). Disease-free survival for pT1a and pT1b tumors was worse in HER2 (82%) than in triple-negative (90%), luminal B (95%) and luminal A (97%) (P = 0.013). Finally, luminal B patients had a significantly higher rate of second non-mammary tumors than the other groups. CONCLUSIONS: In the pre-trastuzumab era, luminal A patients showed a better 5-year overall survival than luminal B, HER2 and triple-negative patients, but in terms of disease-free survival, HER2 subtype represented an unfavorable group over time, whereas the triple-negative group had an increased risk of relapse in the first 42 months and then decreased. Among each prognostic factor, ER <10%, Ki67 >14% and HER2 overexpression are considered as risk factors, but only HER2 positivity seems to preserve the role over time.
Authors: Grazia Palomba; Angela Loi; Eleonora Porcu; Antonio Cossu; Ilenia Zara; Mario Budroni; Mariano Dei; Sandra Lai; Antonella Mulas; Nina Olmeo; Maria Teresa Ionta; Francesco Atzori; Gianmauro Cuccuru; Maristella Pitzalis; Magdalena Zoledziewska; Nazario Olla; Mario Lovicu; Marina Pisano; Gonçalo R Abecasis; Manuela Uda; Francesco Tanda; Kyriaki Michailidou; Douglas F Easton; Stephen J Chanock; Robert N Hoover; David J Hunter; David Schlessinger; Serena Sanna; Laura Crisponi; Giuseppe Palmieri Journal: BMC Cancer Date: 2015-05-10 Impact factor: 4.430
Authors: Gøril Knutsvik; Ingunn M Stefansson; Sura Aziz; Jarle Arnes; Johan Eide; Karin Collett; Lars A Akslen Journal: PLoS One Date: 2014-11-06 Impact factor: 3.240
Authors: Keith T Flaherty; Robert Gray; Alice Chen; Shuli Li; David Patton; Stanley R Hamilton; Paul M Williams; Edith P Mitchell; A John Iafrate; Jeffrey Sklar; Lyndsay N Harris; Lisa M McShane; Larry V Rubinstein; David J Sims; Mark Routbort; Brent Coffey; Tony Fu; James A Zwiebel; Richard F Little; Donna Marinucci; Robert Catalano; Rick Magnan; Warren Kibbe; Carol Weil; James V Tricoli; Brian Alexander; Shaji Kumar; Gary K Schwartz; Funda Meric-Bernstam; Chih-Jian Lih; Worta McCaskill-Stevens; Paolo Caimi; Naoko Takebe; Vivekananda Datta; Carlos L Arteaga; Jeffrey S Abrams; Robert Comis; Peter J O'Dwyer; Barbara A Conley Journal: J Natl Cancer Inst Date: 2020-10-01 Impact factor: 13.506