Morphogenetic aspects of biomineralization on the background of benign prostatic hyperplasia.

Despite the considerable spread of pathological prostate inclusions their nature and significance in the development of gland pathology are not established exactly. The work includes histological research of 628 surgical biopsies of benign prostatic hyperplasia, the sections were stained with hematoxylin and eosin or Congo red, von Kossa methods. Mineral constituent of prostatoliths (5 cases) was studied by infrared spectroscopy (IRS); scanning electron microscopy with X-ray microanalysis (REMMA/EDX), transmission electron microscopy and electron diffraction (TEM/ED). The average age of the operated patients was 69,5±0,42 years old. In 88,22±1,67% of cases nodular prostatic hyperplasia was combined with diffuse or focal inflammation, engorgements of prostate gland secretion were observed in 81,76±2,97%. In the lumen of the prostate gland corpora amylacea were detected in 64,72±1,13% of cases, in 27,6±3,48% - concreations. There was a significant strong correlation between inflammation and calculi - r = 0.93 (p<0,05), inflammation and secret engorgement - r=0,95 (p<0,05), engorgement and concreations - r = 0,88 (p <0,05). TEM results show the same morphological type of prostatolith crystals and their small size (tens of nanometers), that indicates their preferential formation by direct sedimentation from the liquid phase, rather than the appearance and maturation of corpora amylacea on the surface. Based on the received data, the dominant mechanism of concrements formation is precipitation by direct sedimentation of prostate secretions, but it's not a dystrophic calcification of the corpora amylacea. Mineral component of prostatic concrements is carbonate bioapatite with a minor inclusion of other chemical elements.