BACKGROUND: Preoperatively elevated neutrophil/lymphocyte ratio (NLR) is a negative prognostic factor of survival in various types of cancers. A retrospective study was conducted to examine if preoperative elevation of NLR is associated with higher risk for incidental papillary thyroid microcarcinoma (PTMC). METHODS: The study sample consisted of 26 patients with benign goiters, 31 patients with incidental PTMC, 26 patients preoperatively diagnosed with thyroid cancer, and 26 healthy controls. NLRs were compared regarding thyroidal pathology. RESULTS: The mean preoperative NLR was significantly elevated in patients with PTMC and thyroid cancer. In addition, the third and fourth quartiles of NLR included only patients with either PTMC or thyroid cancer. No significant differences in NLR occurred between patients with multifocal and unifocal PTMC. CONCLUSIONS: NLRs were significantly elevated in patients with incidental PTMC and thyroid cancer. The findings of this pilot study indicate that NLR should be considered an easily accessible biomarker for detecting incidental PTCM; nevertheless, further studies are required to confirm these preliminary results.
BACKGROUND: Preoperatively elevated neutrophil/lymphocyte ratio (NLR) is a negative prognostic factor of survival in various types of cancers. A retrospective study was conducted to examine if preoperative elevation of NLR is associated with higher risk for incidental papillary thyroid microcarcinoma (PTMC). METHODS: The study sample consisted of 26 patients with benign goiters, 31 patients with incidental PTMC, 26 patients preoperatively diagnosed with thyroid cancer, and 26 healthy controls. NLRs were compared regarding thyroidal pathology. RESULTS: The mean preoperative NLR was significantly elevated in patients with PTMC and thyroid cancer. In addition, the third and fourth quartiles of NLR included only patients with either PTMC or thyroid cancer. No significant differences in NLR occurred between patients with multifocal and unifocal PTMC. CONCLUSIONS: NLRs were significantly elevated in patients with incidental PTMC and thyroid cancer. The findings of this pilot study indicate that NLR should be considered an easily accessible biomarker for detecting incidental PTCM; nevertheless, further studies are required to confirm these preliminary results.
Authors: Mehmet Buğra Bozan; Fatih Mehmet Yazar; İlhami Taner Kale; Mehmet Fatih Yüzbaşıoğlu; Ömer Faruk Boran; Ayşe Azak Bozan Journal: World J Surg Date: 2020-10-16 Impact factor: 3.352
Authors: Brian Hung-Hin Lang; Cathy Po-Ching Ng; Kin Bun Au; Kai Pun Wong; Kandy K C Wong; Koon Yat Wan Journal: World J Surg Date: 2014-10 Impact factor: 3.352
Authors: Mustafa Çolak; Fakih Cihat Eravcı; Süleyman Emre Karakurt; Mehmet Fatih Karakuş; Aykut İkincioğulları; Kürşat Murat Özcan Journal: Indian J Otolaryngol Head Neck Surg Date: 2019-06-05
Authors: Kellie A Charles; Benjamin D W Harris; Carol R Haddad; Stephen J Clarke; Alex Guminski; Mark Stevens; Tristan Dodds; Anthony J Gill; Michael Back; David Veivers; Thomas Eade Journal: BMC Cancer Date: 2016-02-18 Impact factor: 4.430