PURPOSE: The authors present a stochastic framework for the assessment of cell survival in gold nanoparticle radiotherapy. METHODS: The authors derive the equations for the effective macroscopic dose enhancement for a population of cells with nonideal distribution of gold nanoparticles (GNP), allowing different number of GNP per cell and different distances with respect to the cellular target. They use the mixed Poisson distribution formalism to model the impact of the aforementioned physical factors on the effective dose enhancement. RESULTS: The authors show relatively large differences in the estimation of cell survival arising from using approximated formulae. They predict degeneration of the cell killing capacity due to different number of GNP per cell and different distances with respect to the cellular target. CONCLUSIONS: The presented stochastic framework can be used in interpretation of experimental cell survival or tumor control probability studies.
PURPOSE: The authors present a stochastic framework for the assessment of cell survival in gold nanoparticle radiotherapy. METHODS: The authors derive the equations for the effective macroscopic dose enhancement for a population of cells with nonideal distribution of gold nanoparticles (GNP), allowing different number of GNP per cell and different distances with respect to the cellular target. They use the mixed Poisson distribution formalism to model the impact of the aforementioned physical factors on the effective dose enhancement. RESULTS: The authors show relatively large differences in the estimation of cell survival arising from using approximated formulae. They predict degeneration of the cell killing capacity due to different number of GNP per cell and different distances with respect to the cellular target. CONCLUSIONS: The presented stochastic framework can be used in interpretation of experimental cell survival or tumor control probability studies.
Authors: Lucie Dobešová; Theresa Gier; Olga Kopečná; Eva Pagáčová; Tomáš Vičar; Felix Bestvater; Jiří Toufar; Alena Bačíková; Pavel Kopel; Radek Fedr; Georg Hildenbrand; Iva Falková; Martin Falk; Michael Hausmann Journal: Pharmaceutics Date: 2022-01-11 Impact factor: 6.321