Louise M Stewart1, C D'Arcy J Holman, Judith C Finn, David B Preen, Roger Hart. 1. School of Population Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, M431, 35 Stirling Highway, Crawley, WA 6009, Australia. louise.stewart@uwa.edu.au
Abstract
OBJECTIVES: To compare the risk of borderline ovarian tumours in women having in vitro fertilization (IVF) with women diagnosed with infertility but not having IVF. METHODS: This was a whole-population cohort study of women aged 20-44 years seeking hospital infertility treatment or investigation in Western Australia in 1982-2002. Using Cox regression, we examined the effects of IVF treatment and potential confounders on the rate of borderline ovarian tumours. Potential confounders included parity, age, calendar year, socio-economic status, infertility diagnoses including pelvic inflammatory disorders and endometriosis and surgical procedures including hysterectomy and tubal ligation. RESULTS: Women undergoing IVF had an increased rate of borderline ovarian tumours with a hazard ratio (HR) of 2.46 (95% confidence interval [CI] 1.20-5.04). Unlike invasive epithelial ovarian cancer, neither birth (HR 0.89; 95% CI 0.43-1.88) nor hysterectomy (1.02; 0.24-4.37) nor sterilization (1.48; 0.63-3.48) appeared protective and the rate was not increased in women with a diagnosis of endometriosis (HR 0.31; 95% CI 0.04-2.29). CONCLUSIONS: Women undergoing IVF treatment are at increased risk of being diagnosed with borderline ovarian tumours. Risk factors for borderline ovarian tumours appear different from those for invasive ovarian cancer.
OBJECTIVES: To compare the risk of borderline ovarian tumours in women having in vitro fertilization (IVF) with women diagnosed with infertility but not having IVF. METHODS: This was a whole-population cohort study of women aged 20-44 years seeking hospital infertility treatment or investigation in Western Australia in 1982-2002. Using Cox regression, we examined the effects of IVF treatment and potential confounders on the rate of borderline ovarian tumours. Potential confounders included parity, age, calendar year, socio-economic status, infertility diagnoses including pelvic inflammatory disorders and endometriosis and surgical procedures including hysterectomy and tubal ligation. RESULTS: Women undergoing IVF had an increased rate of borderline ovarian tumours with a hazard ratio (HR) of 2.46 (95% confidence interval [CI] 1.20-5.04). Unlike invasive epithelial ovarian cancer, neither birth (HR 0.89; 95% CI 0.43-1.88) nor hysterectomy (1.02; 0.24-4.37) nor sterilization (1.48; 0.63-3.48) appeared protective and the rate was not increased in women with a diagnosis of endometriosis (HR 0.31; 95% CI 0.04-2.29). CONCLUSIONS: Women undergoing IVF treatment are at increased risk of being diagnosed with borderline ovarian tumours. Risk factors for borderline ovarian tumours appear different from those for invasive ovarian cancer.
Authors: Mandy Spaan; Alexandra W van den Belt-Dusebout; Cornelis B Lambalk; Hester H van Boven; Roel Schats; Marian Kortman; Frank J M Broekmans; Joop S E Laven; Evert J P van Santbrink; Didi D M Braat; Lucette A J van der Westerlaken; Ben J Cohlen; Astrid E P Cantineau; Jesper M J Smeenk; Minouche M van Rumste; Mariëtte Goddijn; Ron J T van Golde; Paul A M Meeuwissen; Carl J C M Hamilton; Gabriële M Ouwens; Miranda A Gerritsma; Michael Schaapveld; Curt W Burger; Flora E van Leeuwen Journal: J Natl Cancer Inst Date: 2021-06-01 Impact factor: 13.506
Authors: Louise M Stewart; C D'Arcy J Holman; James B Semmens; David Preen; Qun Mai; Roger Hart Journal: PLoS One Date: 2015-03-25 Impact factor: 3.240
Authors: Yingchang Lu; Alicia Beeghly-Fadiel; Lang Wu; Xingyi Guo; Bingshan Li; Joellen M Schildkraut; Hae Kyung Im; Yian A Chen; Jennifer B Permuth; Brett M Reid; Jamie K Teer; Kirsten B Moysich; Irene L Andrulis; Hoda Anton-Culver; Banu K Arun; Elisa V Bandera; Rosa B Barkardottir; Daniel R Barnes; Javier Benitez; Line Bjorge; James Brenton; Ralf Butzow; Trinidad Caldes; Maria A Caligo; Ian Campbell; Jenny Chang-Claude; Kathleen B M Claes; Fergus J Couch; Daniel W Cramer; Mary B Daly; Anna deFazio; Joe Dennis; Orland Diez; Susan M Domchek; Thilo Dörk; Douglas F Easton; Diana M Eccles; Peter A Fasching; Renée T Fortner; George Fountzilas; Eitan Friedman; Patricia A Ganz; Judy Garber; Graham G Giles; Andrew K Godwin; David E Goldgar; Marc T Goodman; Mark H Greene; Jacek Gronwald; Ute Hamann; Florian Heitz; Michelle A T Hildebrandt; Claus K Høgdall; Antoinette Hollestelle; Peter J Hulick; David G Huntsman; Evgeny N Imyanitov; Claudine Isaacs; Anna Jakubowska; Paul James; Beth Y Karlan; Linda E Kelemen; Lambertus A Kiemeney; Susanne K Kjaer; Ava Kwong; Nhu D Le; Goska Leslie; Fabienne Lesueur; Douglas A Levine; Amalia Mattiello; Taymaa May; Lesley McGuffog; Iain A McNeish; Melissa A Merritt; Francesmary Modugno; Marco Montagna; Susan L Neuhausen; Heli Nevanlinna; Finn C Nielsen; Liene Nikitina-Zake; Robert L Nussbaum; Kenneth Offit; Edith Olah; Olufunmilayo I Olopade; Sara H Olson; Håkan Olsson; Ana Osorio; Sue K Park; Michael T Parsons; Petra H M Peeters; Tanja Pejovic; Paolo Peterlongo; Catherine M Phelan; Miquel Angel Pujana; Susan J Ramus; Gad Rennert; Harvey Risch; Gustavo C Rodriguez; Cristina Rodríguez-Antona; Isabelle Romieu; Matti A Rookus; Mary Anne Rossing; Iwona K Rzepecka; Dale P Sandler; Rita K Schmutzler; Veronica W Setiawan; Priyanka Sharma; Weiva Sieh; Jacques Simard; Christian F Singer; Honglin Song; Melissa C Southey; Amanda B Spurdle; Rebecca Sutphen; Anthony J Swerdlow; Manuel R Teixeira; Soo H Teo; Mads Thomassen; Marc Tischkowitz; Amanda E Toland; Antonia Trichopoulou; Nadine Tung; Shelley S Tworoger; Elizabeth J van Rensburg; Adriaan Vanderstichele; Ana Vega; Digna Velez Edwards; Penelope M Webb; Jeffrey N Weitzel; Nicolas Wentzensen; Emily White; Alicja Wolk; Anna H Wu; Drakoulis Yannoukakos; Kristin K Zorn; Simon A Gayther; Antonis C Antoniou; Andrew Berchuck; Ellen L Goode; Georgia Chenevix-Trench; Thomas A Sellers; Paul D P Pharoah; Wei Zheng; Jirong Long Journal: Cancer Res Date: 2018-07-27 Impact factor: 13.312