Literature DB >> 23384772

Therapeutic potential of neuregulin-1 in cardiovascular disease.

Pedro Mendes-Ferreira1, Gilles W De Keulenaer, Adelino F Leite-Moreira, Carmen Brás-Silva.   

Abstract

Neuregulin-1 (NRG-1)/ErbB signaling has an indispensable role in cardiac development and in the maintenance of the structural and functional integrity of the human adult heart in health and disease. Several animal studies have now demonstrated the therapeutic effects of NRG-1 during acute cardiac injury and during chronic heart failure, with improvements in cardiac performance and animal survival. Phase I and II clinical trials for chronic heart failure in humans are now in progress.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23384772     DOI： 10.1016/j.drudis.2013.01.010

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  14 in total

1.  Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.

Authors:  Robert Fledrich; Ruth M Stassart; Axel Klink; Lennart M Rasch; Thomas Prukop; Lauren Haag; Dirk Czesnik; Theresa Kungl; Tamer A M Abdelaal; Naureen Keric; Christine Stadelmann; Wolfgang Brück; Klaus-Armin Nave; Michael W Sereda
Journal:  Nat Med       Date:  2014-08-24       Impact factor: 53.440

2.  In vitro and in vivo single myosin step-sizes in striated muscle.

Authors:  Thomas P Burghardt; Xiaojing Sun; Yihua Wang; Katalin Ajtai
Journal:  J Muscle Res Cell Motil       Date:  2016-01-04       Impact factor: 2.698

3.  Hypoxia pretreatment improves the therapeutic potential of bone marrow mesenchymal stem cells in hindlimb ischemia via upregulation of NRG-1.

Authors:  Xitao Peng; Bing Liang; Haisheng Wang; Jingyuan Hou; Qidong Yuan
Journal:  Cell Tissue Res       Date:  2022-01-29       Impact factor: 5.249

Review 4.  Neuregulin as a heart failure therapy and mediator of reverse remodeling.

Authors:  Cristi L Galindo; Sergey Ryzhov; Douglas B Sawyer
Journal:  Curr Heart Fail Rep       Date:  2014-03

Review 5.  Translational aspects of cardiac cell therapy.

Authors:  Cheng-Han Chen; Konstantina-Ioanna Sereti; Benjamin M Wu; Reza Ardehali
Journal:  J Cell Mol Med       Date:  2015-06-27       Impact factor: 5.310

6.  Analytical comparison of natural and pharmaceutical ventricular myosin activators.

Authors:  Yihua Wang; Katalin Ajtai; Thomas P Burghardt
Journal:  Biochemistry       Date:  2014-08-07       Impact factor: 3.162

Review 7.  The roles of neuregulin-1 in cardiac development, homeostasis, and disease.

Authors:  Cassady E Rupert; Kareen Lk Coulombe
Journal:  Biomark Insights       Date:  2015-04-08

8.  Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function.

Authors:  Margaret E McCormick; Caitlin Collins; Catherine A Makarewich; Zhongming Chen; Mauricio Rojas; Monte S Willis; Steven R Houser; Ellie Tzima
Journal:  J Am Heart Assoc       Date:  2015-01-19       Impact factor: 5.501

Review 9.  ErbB2 signaling at the crossing between heart failure and cancer.

Authors:  Zarha Vermeulen; Vincent F M Segers; Gilles W De Keulenaer
Journal:  Basic Res Cardiol       Date:  2016-09-05       Impact factor: 17.165

10.  Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model.

Authors:  Xin Lai; Liang Zhong; Hai-Xia Fu; Song Dang; Xin Wang; Ning Zhang; Gao-Ke Feng; Zi-Qiang Liu; Xi Wang; Long Wang
Journal:  Neural Regen Res       Date:  2017-11       Impact factor: 5.135
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