BACKGROUND AND OBJECTIVES: The purpose of our studies was to determine the effects of extended platelet storage on poststorage platelet viability. MATERIALS AND METHODS: Normal subjects were recruited to donate platelets using two different apheresis systems: either the COBE Spectra (n = 58) or the Haemonetics MCS+ (n = 84). Platelet recovery and survival data from the two systems were compared with each other and with in vitro measurements of the stored platelets. RESULTS: There were no significant differences in either platelet recoveries or survivals between the two machines between 1 and 8 days of storage. Combining the data from both machines, platelet recoveries decreased by 2.6% and survivals by 0.3 days/storage day. In vitro assays did not predict either platelet recoveries or survivals during storage for 5-8 days. After 9 days of storage, pHs were unacceptable (≤ 6.1), suggesting that 8 days will be the longest possible storage time. CONCLUSIONS: These data suggest that, if stored platelet bacterial contamination issues are resolved, significant extension of platelet storage times is possible.
BACKGROUND AND OBJECTIVES: The purpose of our studies was to determine the effects of extended platelet storage on poststorage platelet viability. MATERIALS AND METHODS: Normal subjects were recruited to donate platelets using two different apheresis systems: either the COBE Spectra (n = 58) or the Haemonetics MCS+ (n = 84). Platelet recovery and survival data from the two systems were compared with each other and with in vitro measurements of the stored platelets. RESULTS: There were no significant differences in either platelet recoveries or survivals between the two machines between 1 and 8 days of storage. Combining the data from both machines, platelet recoveries decreased by 2.6% and survivals by 0.3 days/storage day. In vitro assays did not predict either platelet recoveries or survivals during storage for 5-8 days. After 9 days of storage, pHs were unacceptable (≤ 6.1), suggesting that 8 days will be the longest possible storage time. CONCLUSIONS: These data suggest that, if stored platelet bacterial contamination issues are resolved, significant extension of platelet storage times is possible.
Authors: Larry J Dumont; James P AuBuchon; Pamela Whitley; Louise H Herschel; Adrienne Johnson; Deanna McNeil; Sherrie Sawyer; Jill C Roger Journal: Transfusion Date: 2002-07 Impact factor: 3.157
Authors: Sherrill J Slichter; Doug Bolgiano; Mary Kay Jones; Todd Christoffel; Jill Corson; Leslie Rose; Jim Foley; Mark Popovsky; Laurene L Baril; Tammy Corda; Dorothy M Dincecco; Edward L Snyder Journal: Transfusion Date: 2006-10 Impact factor: 3.157
Authors: Steven Kleinman; Larry J Dumont; Peter Tomasulo; Celso Bianco; Louis Katz; Richard J Benjamin; Ognjen Gajic; Mark E Brecher Journal: Transfusion Date: 2009-01-05 Impact factor: 3.157