PURPOSE: As more young female patients with cancer survive their primary disease, concerns about reproductive health related to primary therapy gain relevance. Cancer therapy can often affect reproductive organs, leading to impaired pubertal development, hormonal regulation, fertility, and sexual function, affecting quality of life. METHODS: The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer (COG-LTFU Guidelines) are evidence-based recommendations for screening and management of late effects of therapeutic exposures. The guidelines are updated every 2 years by a multidisciplinary panel based on current literature review and expert consensus. RESULTS: This review summarizes the current task force recommendations for the assessment and management of female reproductive complications after treatment for childhood, adolescent, and young adult cancers. Experimental pretreatment as well as post-treatment fertility preservation strategies, including barriers and ethical considerations, which are not included in the COG-LTFU Guidelines, are also discussed. CONCLUSION: Ongoing research will continue to inform COG-LTFU Guideline recommendations for follow-up care of female survivors of childhood cancer to improve their health and quality of life.
PURPOSE: As more young female patients with cancer survive their primary disease, concerns about reproductive health related to primary therapy gain relevance. Cancer therapy can often affect reproductive organs, leading to impaired pubertal development, hormonal regulation, fertility, and sexual function, affecting quality of life. METHODS: The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer (COG-LTFU Guidelines) are evidence-based recommendations for screening and management of late effects of therapeutic exposures. The guidelines are updated every 2 years by a multidisciplinary panel based on current literature review and expert consensus. RESULTS: This review summarizes the current task force recommendations for the assessment and management of female reproductive complications after treatment for childhood, adolescent, and young adult cancers. Experimental pretreatment as well as post-treatment fertility preservation strategies, including barriers and ethical considerations, which are not included in the COG-LTFU Guidelines, are also discussed. CONCLUSION: Ongoing research will continue to inform COG-LTFU Guideline recommendations for follow-up care of female survivors of childhood cancer to improve their health and quality of life.
Authors: Daniel M Green; Jane M Lange; Eve M Peabody; Natalia N Grigorieva; Susan M Peterson; John A Kalapurakal; Norman E Breslow Journal: J Clin Oncol Date: 2010-05-10 Impact factor: 44.544
Authors: Mark F H Brougham; Patricia M Crofton; Emma J Johnson; Nancy Evans; Richard A Anderson; W Hamish B Wallace Journal: J Clin Endocrinol Metab Date: 2012-04-03 Impact factor: 5.958
Authors: L Del Mastro; T Catzeddu; L Boni; C Bell; M R Sertoli; C Bighin; M Clavarezza; D Testa; M Venturini Journal: Ann Oncol Date: 2005-10-27 Impact factor: 32.976
Authors: Anne Z Steiner; Amy H Herring; James S Kesner; Juliana W Meadows; Frank Z Stanczyk; Steven Hoberman; Donna D Baird Journal: Obstet Gynecol Date: 2011-04 Impact factor: 7.661
Authors: Sheri L Spunt; Teresa A Sweeney; Melissa M Hudson; Catherine A Billups; Matthew J Krasin; Allison L Hester Journal: J Clin Oncol Date: 2005-10-01 Impact factor: 44.544
Authors: A La Marca; G Sighinolfi; D Radi; C Argento; E Baraldi; A Carducci Artenisio; G Stabile; A Volpe Journal: Hum Reprod Update Date: 2009-09-30 Impact factor: 15.610
Authors: Ann C Mertens; Yutaka Yasui; Yan Liu; Marilyn Stovall; Ray Hutchinson; Jill Ginsberg; Charles Sklar; Leslie L Robison Journal: Cancer Date: 2002-12-01 Impact factor: 6.921
Authors: Sana M Salih; Sarah Z Elsarrag; Elizabeth Prange; Karli Contreras; Radya G Osman; Jens C Eikoff; Diane Puccetti Journal: J Pediatr Adolesc Gynecol Date: 2014-06-07 Impact factor: 1.814
Authors: Wassim Chemaitilly; Zhenghong Li; Matthew J Krasin; Russell J Brooke; Carmen L Wilson; Daniel M Green; James L Klosky; Nicole Barnes; Karen L Clark; Jonathan B Farr; Israel Fernandez-Pineda; Michael W Bishop; Monika Metzger; Ching-Hon Pui; Sue C Kaste; Kirsten K Ness; Deo Kumar Srivastava; Leslie L Robison; Melissa M Hudson; Yutaka Yasui; Charles A Sklar Journal: J Clin Endocrinol Metab Date: 2017-07-01 Impact factor: 5.958
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Authors: Francesca E Duncan; Mary Ellen Pavone; Alexander H Gunn; Sherif Badawy; Clarisa Gracia; Jill P Ginsberg; Barbara Lockart; Yasmin Gosiengfiao; Teresa K Woodruff Journal: J Adolesc Young Adult Oncol Date: 2015-12 Impact factor: 2.223
Authors: Jessica R Gorman; Brian W Whitcomb; Daniel Standridge; Vanessa L Malcarne; Sally A D Romero; Samantha A Roberts; H Irene Su Journal: J Cancer Surviv Date: 2016-09-30 Impact factor: 4.442
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