Literature DB >> 23381110

Antibody therapeutics targeting ion channels: are we there yet?

Han Sun1, Min Li.   

Abstract

The combination of technological advances, genomic sequences and market success is catalyzing rapid development of antibody-based therapeutics. Cell surface receptors and ion channel proteins are well known drug targets, but the latter has seen less success. The availability of crystal structures, better understanding of gating biophysics and validation of physiological roles now form an excellent foundation to pursue antibody-based therapeutics targeting ion channels to treat a variety of diseases.

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Year:  2013        PMID： 23381110      PMCID： PMC4011603          DOI： 10.1038/aps.2012.202

Source DB:  PubMed          Journal:  Acta Pharmacol Sin        ISSN： 1671-4083            Impact factor:   6.150


  44 in total

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Authors:  Hisanori Tomimitsu; Kimiyoshi Arimura; Tatsui Nagado; Osamu Watanabe; Reika Otsuka; Asutsugu Kurono; Yoshito Sonoda; Mitsuhiro Osame; Masaki Kameyama
Journal:  Ann Neurol       Date:  2004-09       Impact factor: 10.422

2.  Expression and functional role of bTRPC1 channels in native endothelial cells.

Authors:  Susanna Antoniotti; Davide Lovisolo; Alessandra Fiorio Pla; Luca Munaron
Journal:  FEBS Lett       Date:  2002-01-16       Impact factor: 4.124

3.  Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.

Authors:  Y Joy Yu; Yin Zhang; Margaret Kenrick; Kwame Hoyte; Wilman Luk; Yanmei Lu; Jasvinder Atwal; J Michael Elliott; Saileta Prabhu; Ryan J Watts; Mark S Dennis
Journal:  Sci Transl Med       Date:  2011-05-25       Impact factor: 17.956

4.  Monoclonal antibodies associated with sodium channel block nerve impulse and stain nodes of Ranvier.

Authors:  H Meiri; I Zeitoun; H H Grunhagen; V Lev-Ram; Z Eshhar; J Schlessinger
Journal:  Brain Res       Date:  1984-09-17       Impact factor: 3.252

5.  Isolation and characterization of a monoclonal antibody against the saxitoxin-binding component from the electric organ of the eel Electrophorus electricus.

Authors:  H P Moore; L C Fritz; M A Raftery; J P Brockes
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

6.  TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells.

Authors:  S Z Xu; D J Beech
Journal:  Circ Res       Date:  2001-01-19       Impact factor: 17.367

Review 7.  Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier.

Authors:  William M Pardridge; Ruben J Boado
Journal:  Methods Enzymol       Date:  2012       Impact factor: 1.600

8.  Potassium channel KIR4.1 as an immune target in multiple sclerosis.

Authors:  Rajneesh Srivastava; Muhammad Aslam; Sudhakar Reddy Kalluri; Lucas Schirmer; Dorothea Buck; Björn Tackenberg; Veit Rothhammer; Andrew Chan; Ralf Gold; Achim Berthele; Jeffrey L Bennett; Thomas Korn; Bernhard Hemmer
Journal:  N Engl J Med       Date:  2012-07-12       Impact factor: 91.245

9.  Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells.

Authors:  Gias U Ahmmed; Dolly Mehta; Stephen Vogel; Michael Holinstat; Biman C Paria; Chinnaswamy Tiruppathi; Asrar B Malik
Journal:  J Biol Chem       Date:  2004-03-10       Impact factor: 5.157

10.  Endogenously expressed Trp1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets.

Authors:  Juan A Rosado; Sharon L Brownlow; Stewart O Sage
Journal:  J Biol Chem       Date:  2002-08-23       Impact factor: 5.157
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  10 in total

1.  A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief.

Authors:  Jun-Ho Lee; Chul-Kyu Park; Gang Chen; Qingjian Han; Rou-Gang Xie; Tong Liu; Ru-Rong Ji; Seok-Yong Lee
Journal:  Cell       Date:  2014-05-22       Impact factor: 41.582

Review 2.  Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential.

Authors:  Daniela Gavello; Emilio Carbone; Valentina Carabelli
Journal:  Channels (Austin)       Date:  2016-03-28       Impact factor: 2.581

Review 3.  Controlling ion channel function with renewable recombinant antibodies.

Authors:  Henry M Colecraft; James S Trimmer
Journal:  J Physiol       Date:  2022-03-17       Impact factor: 6.228

4.  Affimer proteins are versatile and renewable affinity reagents.

Authors:  Christian Tiede; Robert Bedford; Sophie J Heseltine; Gina Smith; Imeshi Wijetunga; Rebecca Ross; Danah AlQallaf; Ashley Pe Roberts; Alexander Balls; Alistair Curd; Ruth E Hughes; Heather Martin; Sarah R Needham; Laura C Zanetti-Domingues; Yashar Sadigh; Thomas P Peacock; Anna A Tang; Naomi Gibson; Hannah Kyle; Geoffrey W Platt; Nicola Ingram; Thomas Taylor; Louise P Coletta; Iain Manfield; Margaret Knowles; Sandra Bell; Filomena Esteves; Azhar Maqbool; Raj K Prasad; Mark Drinkhill; Robin S Bon; Vikesh Patel; Sarah A Goodchild; Marisa Martin-Fernandez; Ray J Owens; Joanne E Nettleship; Michael E Webb; Michael Harrison; Jonathan D Lippiat; Sreenivasan Ponnambalam; Michelle Peckham; Alastair Smith; Paul Ko Ferrigno; Matt Johnson; Michael J McPherson; Darren Charles Tomlinson
Journal:  Elife       Date:  2017-06-27       Impact factor: 8.140

5.  Going native: Direct high throughput screening of secreted full-length IgG antibodies against cell membrane proteins.

Authors:  Yongliang Fang; Thach H Chu; Margaret E Ackerman; Karl E Griswold
Journal:  MAbs       Date:  2017-09-21       Impact factor: 5.857

Review 6.  Ion channels as therapeutic antibody targets.

Authors:  Catherine J Hutchings; Paul Colussi; Theodore G Clark
Journal:  MAbs       Date:  2018-12-10       Impact factor: 5.857

7.  Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS.

Authors:  Yunhee Jo; Jiwon Lee; Seul-Yi Lee; Ilmin Kwon; Hana Cho
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-08       Impact factor: 11.205

Review 8.  Potassium Channels as a Target for Cancer Therapy: Current Perspectives.

Authors:  Leandro Zúñiga; Angel Cayo; Wendy González; Cristian Vilos; Rafael Zúñiga
Journal:  Onco Targets Ther       Date:  2022-07-20       Impact factor: 4.345

9.  A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.

Authors:  Han Sun; Liqun Luo; Bachchu Lal; Xinrong Ma; Lieping Chen; Christine L Hann; Amy M Fulton; Daniel J Leahy; John Laterra; Min Li
Journal:  Nat Commun       Date:  2016-02-04       Impact factor: 14.919

Review 10.  A Revised View on the Role of Surface AMPAR Mobility in Tuning Synaptic Transmission: Limitations, Tools, and Alternative Views.

Authors:  Jary Y Delgado; Paul R Selvin
Journal:  Front Synaptic Neurosci       Date:  2018-07-20
  10 in total

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